NHP2 antibody

Catalog No. ABIN6570220

Product Details anti-NHP2 Antibody

Target: NHP2 (NHP2 Ribonucleoprotein (NHP2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NHP2 antibody is un-conjugated

Application: Western Blotting (WB)

Purification: Affinity purification

Immunogen: Recombinant protein of human NHP2

Isotype: IgG

Application Details

Application Notes: WB 1:500 - 1:2000

Restrictions: For Research Use only

Handling

Concentration: 1 mg/mL

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol,  pH 7.3.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for NHP2

Target: NHP2 (NHP2 Ribonucleoprotein (NHP2))

Alternative Name: NHP2 (NHP2 Products)

Synonyms: DKCB2 antibody, NHP2P antibody, NOLA2 antibody, 2410130M07Rik antibody, D11Ertd175e antibody, Nola2 antibody, NHP2 ribonucleoprotein antibody, NHP2 antibody, Nhp2 antibody

Background:

Synonyms: DKCB2,FLJ20479,H/ACA ribonucleoprotein complex subunit 2,NHP2,NHP2 like protein,NHP2 ribonucleoprotein,NHP2 ribonucleoprotein homolog (yeast) 1,NHP2 ribonucleoprotein homolog,NHP2, S. cerevisiae, homolog of,NHP2,NHP2P,NOLA2,Nucleolar protein family A member 2 (H/ACA small nucleolar RNPs),Nucleolar protein family A member 2,snoRNP protein NHP2

Background: This gene is a member of the H/ACA snoRNPs (small nucleolar ribonucleoproteins) gene family. snoRNPs are involved in various aspects of rRNA processing and modification and have been classified into two families: C/D and H/ACA. The H/ACA snoRNPs also include the DKC1, NOLA1 and NOLA3 proteins. These four H/ACA snoRNP proteins localize to the dense fibrillar components of nucleoli and to coiled (Cajal) bodies in the nucleus. Both 18S rRNA production and rRNA pseudouridylation are impaired if any one of the four proteins is depleted. The four H/ACA snoRNP proteins are also components of the telomerase complex. This gene encodes a protein related to Saccharomyces cerevisiae Nhp2p. Alternative splicing results in multiple transcript variants.

Molecular Weight:

Observed_MW: 20kDa

Calculated_MW: 17kDa

Gene ID: 55651

UniProt: Q9NX24

Pathways: Telomere Maintenance