TAX1BP3 antibody

Catalog No. ABIN6571899

Product Details anti-TAX1BP3 Antibody

Target: TAX1BP3 (Tax1 (Human T-Cell Leukemia Virus Type I) Binding Protein 3 (TAX1BP3))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TAX1BP3 antibody is un-conjugated

Application: Western Blotting (WB)

Purification: Affinity purification

Immunogen: Recombinant protein of human TAX1BP3

Isotype: IgG

Application Details

Application Notes: WB 1:500 - 1:2000

Restrictions: For Research Use only

Handling

Concentration: 1 mg/mL

Buffer: Buffer: PBS with 0.02 % sodium azide, 50 % glycerol,  pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for TAX1BP3

Target: TAX1BP3 (Tax1 (Human T-Cell Leukemia Virus Type I) Binding Protein 3 (TAX1BP3))

Alternative Name: TAX1BP3 (TAX1BP3 Products)

Synonyms: TIP-1 antibody, 1300011C24Rik antibody, RP23-263M10.10 antibody, tax1bp3 antibody, wu:fb37e03 antibody, wu:fc23g08 antibody, zgc:55513 antibody, Tax1 binding protein 3 antibody, Tax1 (human T cell leukemia virus type I) binding protein 3 antibody, Tax1 (human T-cell leukemia virus type I) binding protein 3 S homeolog antibody, Tax1 (human T-cell leukemia virus type I) binding protein 3 antibody, TAX1BP3 antibody, Tax1bp3 antibody, tax1bp3.S antibody, tax1bp3 antibody

Background:

Synonyms: Glutaminase interacting protein 3,Glutaminase-interacting protein 3,Tax interaction protein 1,Tax1 (human T cell leukemia virus type I) binding protein 3,Tax1 binding protein 3,Tax1-binding protein 3,Tax1bp3,TIP 1,TIP-1,TIP1,TX1B3

Background: This gene encodes a small, highly conserved protein with a single PDZ domain. PDZ (PSD-95/Discs large/ZO-1 homologous) domains promote protein-protein interactions that affect cell signaling, adhesion, protein scaffolding, and receptor and ion transporter functions. The encoded protein interacts with a large number of target proteins that play roles in signaling pathways, for example, it interacts with Rho A and glutaminase L and also acts as a negative regulator of the Wnt/beta-catenin signaling pathway. This protein was first identified as binding to the T-cell leukaemia virus (HTLV1) Tax oncoprotein. Overexpression of this gene has been implicated in altered cancer cell adhesion, migration and metastasis. The encoded protein also modulates the localization and density of inwardly rectifying potassium channel 2.3 (Kir2.3). To date, this protein has been shown to play a role in cell proliferation, development, stress response, and polarization. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

Molecular Weight:

Observed_MW: 14kDa

Calculated_MW: 13kDa

Gene ID: 30851

UniProt: O14907

Pathways: Monocarboxylic Acid Catabolic Process