ACVRL1 antibody (AA 21-70)

Catalog No. ABIN6579294

This Rabbit Polyclonal antibody specifically detects ACVRL1 in WB, ELISA, IHC and IF. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for ACVRL1 antibody (AA 21-70) (ABIN6579294)

Target: ACVRL1 (Activin A Receptor Type II-Like 1 (ACVRL1))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ACVRL1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Product Details anti-ACVRL1 Antibody

Binding Specificity: AA 21-70

Purpose: ALK-1 Antibody

Specificity: ALK-1 Polyclonal Antibody detects endogenous levels of ALK-1 protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: The antiserum was produced against synthesized peptide derived from the N-terminal region of human ACVRL1. AA range:21-70

Isotype: IgG

Application Details

Application Notes: WB 1:500 - 1:2000. IHC: 1:100-300 ELISA: 1:20000.. IF 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C/1 year

Expiry Date: 12 months

Target Details for ACVRL1

Target: ACVRL1 (Activin A Receptor Type II-Like 1 (ACVRL1))

Alternative Name: ACVRL1

Background:

Synonyms: ACVRL1, ACVRLK1, ALK1, Serine/threonine-protein kinase receptor R3, SKR3, Activin receptor-like kinase 1, ALK-1, TGF-B superfamily receptor type I, TSR-I

Background: This gene encodes a type I cell-surface receptor for the TGF-beta superfamily of ligands. It shares with other type I receptors a high degree of similarity in serine-threonine kinase subdomains, a glycine- and serine-rich region (called the GS domain) preceding the kinase domain, and a short C-terminal tail. The encoded protein, sometimes termed ALK1, shares similar domain structures with other closely related ALK or activin receptor-like kinase proteins that form a subfamily of receptor serine/threonine kinases. Mutations in this gene are associated with hemorrhagic telangiectasia type 2, also known as Rendu-Osler-Weber syndrome 2. [provided by RefSeq, Jul 2008],

Gene Name: ACVRL1

Protein Name: Serine/threonine-protein kinase receptor R3

Molecular Weight: 56 kDa

Gene ID: 94

OMIM: 600376

UniProt: P37023