SIGLEC8 antibody (AA 81-130)

Catalog No. ABIN6579554

This Rabbit Polyclonal antibody specifically detects SIGLEC8 in WB and ELISA. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for SIGLEC8 antibody (AA 81-130) (ABIN6579554)

Target: SIGLEC8 (Sialic Acid Binding Ig-Like Lectin 8 (SIGLEC8))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SIGLEC8 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-SIGLEC8 Antibody

Binding Specificity: AA 81-130

Purpose: CD329 Antibody

Specificity: CD329 Polyclonal Antibody detects endogenous levels of CD329 protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: The antiserum was produced against synthesized peptide derived from the Internal region of human SIGLEC8. AA range:81-130

Isotype: IgG

Application Details

Application Notes: WB 1:500 - 1:2000. ELISA: 1:20000. Not yet tested in other applications.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C/1 year

Expiry Date: 12 months

Target Details for SIGLEC8

Target: SIGLEC8 (Sialic Acid Binding Ig-Like Lectin 8 (SIGLEC8))

Alternative Name: SIGLEC8

Background:

Synonyms: SIGLEC8, SAF2, Sialic acid-binding Ig-like lectin 8, Siglec-8, CDw329, Sialoadhesin family member 2, SAF-2, CD329

Background: Sialic acid-binding immunoglobulin (Ig)-like lectins, or SIGLECs (e.g., CD33 (MIM 159590)), are a family of type 1 transmembrane proteins each having a unique expression pattern, mostly in hemopoietic cells. SIGLEC8 is a member of the CD33-like subgroup of SIGLECs, which are localized to 19q13.3-q13.4 and have 2 conserved cytoplasmic tyrosine-based motifs: an immunoreceptor tyrosine-based inhibitory motif, or ITIM (see MIM 604964), and a motif homologous to one identified in signaling lymphocyte activation molecule (SLAM, MIM 603492) that mediates an association with SLAM-associated protein (SAP, MIM 300490) (summarized by Foussias et al., 2000 [PubMed 11095983]).[supplied by OMIM, May 2010],

Gene Name: SIGLEC8

Protein Name: Sialic acid-binding Ig-like lectin 8

Molecular Weight: 54 kDa

Gene ID: 27181

OMIM: 605639

UniProt: Q9NYZ4