COBRA1 antibody (AA 1-252)

Catalog No. ABIN6654201

Product Details anti-COBRA1 Antibody

Target: COBRA1 (Cofactor of BRCA1 (COBRA1))

Binding Specificity: AA 1-252

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This COBRA1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Purification: Antigen affinity purified

Immunogen: Human COBRA1 recombinant protein (amino acids M1-E252) was used as the immunogen for the COBRA1 antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the COBRA1 antibody should be determined by the researcher.\. Western blot: 0.5-1 μg/mL,Direct ELISA: 0.1-0.5 μg/mL (human recombinant protein)

Restrictions: For Research Use only

Handling

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: -20 °C

Storage Comment: After reconstitution, the COBRA1 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Target Details for COBRA1

Target: COBRA1 (Cofactor of BRCA1 (COBRA1))

Alternative Name: COBRA1 (COBRA1 Products)

Synonyms: LOC100219583 antibody, COBRA1 antibody, NELF-B antibody, bZ1O1.4 antibody, cobra1 antibody, cobra2 antibody, fe01e12 antibody, wu:fe01e12 antibody, zgc:55628 antibody, MGC131073 antibody, Cobra1 antibody, RGD1307832 antibody, A730008L03Rik antibody, AB041607 antibody, AI663983 antibody, Nelf-b antibody, cofactor of BRCA1 antibody, negative elongation factor complex member B antibody, negative elongation factor complex member B L homeolog antibody, LOC100219583 antibody, NELFB antibody, nelfb antibody, nelfb.L antibody, Nelfb antibody

Background: Cofactor of BRCA1, also known as COBRA1, is a human gene that encodes NELF-B. NELF-B is a subunit of negative elongation factor (NELF), which also includes NELF-A (WHSC2), either NELF-C or NELF-D (TH1L), and NELF-E (RDBP). NELF acts with DRB sensitivity-inducing factor (DSIF), a heterodimer of SPT4 (SUPT4H1) and SPT5 (SUPT5H), to cause transcriptional pausing of RNA polymerase II. COBRA1 was initially identified in a yeast two-hybrid screen using the BRCT1 domain of BRCA1 as bait.

UniProt: Q8WX92