VEGFR2/CD309 antibody (Extracellular Domain)

Catalog No. ABIN6655552

Supplier Product No.: 200-301-p49

The Mouse Monoclonal anti-VEGFR2/CD309 antibody is suitable to detect VEGFR2/CD309 in samples from Human. It has been validated for IHC.

Quick Overview for VEGFR2/CD309 antibody (Extracellular Domain) (ABIN6655552)

Target: VEGFR2/CD309 (VEGFR2) (VEGF Receptor 2 (VEGFR2))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This VEGFR2/CD309 antibody is un-conjugated

Application: Immunohistochemistry (IHC)

Clone: KDR-1

Product Details anti-VEGFR2/CD309 Antibody

Binding Specificity: Extracellular Domain

Supplier Product No.: 200-301-p49

Supplier: Rockland

Purpose: VEGFR2 Antibody

Cross-Reactivity (Details): This product reacts with human.

Purification: Anti-VEGFR2 antibody was purified from mouse ascites by protein A chromatography.

Immunogen: VEGFR2 antibody was produced in mice by repeated immunizations with recombinant protein corresponding to human extracellular domain of VEGFR-2 (KDR).

Isotype: IgG1

Application Details

Application Notes: Optional[Neutralization_Dilution]: 1:100-1:500

Comment:

Anti-VEGFR2 is tested for Immunohistochemistry-F. Specific conditions for reactivity should be optimized by the end user. Expect a band approximately ~151.5 kDa corresponding to the appropriate cell lysate or extract.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution:

Reconstitution_Buffer: Neutral PBS

Reconstitution_Volume: 1.0 mL

Buffer:

Buffer: 1.2 % sodium acetate

Stabilizer: 2 mg BSA

Preservative: 0.01 % (w/v) Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store vial at 4° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.

Expiry Date: 12 months

Target Details for VEGFR2/CD309

Target: VEGFR2/CD309 (VEGFR2) (VEGF Receptor 2 (VEGFR2))

Alternative Name: VEGFR2

Background:

Synonyms: CD309, VEGFR, FLK1, VEGFR2, TYROSINE KINASE GROWTH FACTOR RECEPTOR, FLK1, MOUSE, HOMOLOG OF, VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR, VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 2, Fetal liver kinase 1, Kinase insert domain receptor, Protein-tyrosine kinase receptor flk-1

Background: VEGF, a homodimeric glycoprotein of relative molecular mass 45,000, is the only mitogen that specifically acts on endothelial cells. The importance of VEGF and its receptor system in tumor growth and intervention in this system may provide promising approaches to cancer therapy. VEGF receptor 2 is a member of a receptor tyrosine kinase family.Like other growth factor receptors, upon ligand binding VEGF receptor 2 dimerises and is autophosphorylated on multiple tyrosine residues. This antibody is suitable for researchers interested in cell signaling and cancer research.

Gene Name: KDR

Gene ID: 3791

NCBI Accession: NP_002244

UniProt: P35968

Pathways: RTK Signaling, Glycosaminoglycan Metabolic Process, Signaling Events mediated by VEGFR1 and VEGFR2, Growth Factor Binding, Regulation of long-term Neuronal Synaptic Plasticity, VEGF Signaling