SCN1A antibody (C-Term)
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- Target See all SCN1A Antibodies
- SCN1A (Sodium Channel, Voltage-Gated, Type I, alpha Subunit (SCN1A))
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Binding Specificity
- C-Term
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Reactivity
- Rat
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Host
- Mouse
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Clonality
- Monoclonal
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Conjugate
- This SCN1A antibody is un-conjugated
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Application
- Immunohistochemistry (IHC), Western Blotting (WB), Immunoprecipitation (IP), Fluorescence Microscopy (FM)
- Cross-Reactivity
- Human, Mouse (Murine), Rat (Rattus)
- Purification
- Anti-Nav1.1 Antibody was purified by Protein G chromatography. A BLAST analysis was used to suggest cross-reactivity with Nav1.1 from Mouse, Human, and Rat based on 100% homology with the immunizing sequence. No cross reactivity against Nav1.2, Nav1.3 and Nav1.6. Cross-reactivity with Nav1.1 from other sources has not been determined. Ion Channels research.
- Immunogen
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Immunogen: Nav1.1 Antibody was produced in mice by repeated immunizations raised against a fusion protein corresponding to the cytoplasmic C-terminus region of rat Nav1.1.
Immunogen Type: Recombinant Protein
- Clone
- S74-71
- Isotype
- IgG1
- Top Product
- Discover our top product SCN1A Primary Antibody
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- Application Notes
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Immunohistochemistry Dilution: 0.1-1.0 μg/mL
Application Note: Anti-Nav1.1 Antibody is suitable for use in WB, IP, and IHC. Expect a band approximately ~220 kDa on specific lysates. Epitope mapped within amino acids 690-715. Specific conditions for reactivity should be optimized by the end user.
Immunoprecipitation Dilution: User Optimized
Western Blot Dilution: 1 μg/mL
IF Microscopy Dilution: 1.0-10 μg/mL
- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
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Buffer: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2
Stabilizer: 50 % (v/v) Glycerol
- Storage
- RT,4 °C,-20 °C
- Storage Comment
- Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.
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- Target
- SCN1A (Sodium Channel, Voltage-Gated, Type I, alpha Subunit (SCN1A))
- Alternative Name
- Nav1.1 (SCN1A Products)
- Synonyms
- SCN9A antibody, SCN1A antibody, B230332M13 antibody, Nav1.1 antibody, EIEE6 antibody, FEB3 antibody, FEB3A antibody, FHM3 antibody, GEFSP2 antibody, HBSCI antibody, NAC1 antibody, SCN1 antibody, SMEI antibody, sodium voltage-gated channel alpha subunit 1 antibody, sodium voltage-gated channel alpha subunit 9 antibody, sodium channel, voltage-gated, type I, alpha antibody, SCN1A antibody, SCN9A antibody, Scn1a antibody
- Background
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Synonyms: FEB3, Scn1a, GEFSP2, HBSCI, SCN1, Sodium channel 3
Background: Voltage gated sodium channels initiate action potentials in neurons. Nav1.1 is abundant in the adult brain, and primarily localized in cell bodies. Mutations in the Nav1.1 channels cause generalized epilepsy with febrile seizures plus (GEFS+). Studies show that Nav1.1 channels also play a crucial role in the excitability of cerebellar Purkinje neurons, with major contributions to peak, persistent and resurgent forms of sodium current and to sustained action potential firing.
Gene Name: Scn1a
- Gene ID
- 20265
- NCBI Accession
- NP_061203
- UniProt
- Q62206
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