PKA antibody (AA 17-100)

Catalog No. ABIN669576

Cited in 4+ publications. The Rabbit Polyclonal anti-PKA antibody (ABIN669576) specifically detects PKA in WB, IF (cc), IF (p), IHC (fro) and IHC (p). The antibody is reactive with Cow samples.

Quick Overview for PKA antibody (AA 17-100) (ABIN669576)

Target: PKA (Protein Kinase A (PKA))

Reactivity: Cow

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PKA antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-PKA Antibody

Binding Specificity: AA 17-100

Purpose: PKA alpha + beta Polyclonal Antibody

Cross-Reactivity: Human, Mouse, Rat

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from bovine PKA

Isotype: IgG

Application Details

Application Notes: WB(1:300-5000),

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4C. Store at -20C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

References for anti-PKA antibody (ABIN669576)

Zhang, Zhao, Zhang, Hao, Yu, Min, Li, Ma, Chen, Yi, Tang, Meng, Liu, Wang, Shen, Zhang: "Decrease in male mouse fertility by hydrogen sulfide and/or ammonia can Be inheritable." in: Chemosphere, Vol. 194, pp. 147-157, (2018) (PubMed).

Zhou, Tanaka, Matsunaga, Iseki, Watanabe, Matsuki, Ikegaya, Koyama: "Photoactivated adenylyl cyclase (PAC) reveals novel mechanisms underlying cAMP-dependent axonal morphogenesis." in: Scientific reports, Vol. 5, pp. 19679, (2016) (PubMed).

Yao, Yue, Yun, Sang: "Chronic SO2 inhalation above environmental standard impairs neuronal behavior and represses glutamate receptor gene expression and memory-related kinase activation via neuroinflammation in rats." in: Environmental research, Vol. 137, pp. 85-93, (2015) (PubMed).

Haolong, Du, Hongchao, Yang, Wei, Hua, Wenliang, Lei, Po: "Enterovirus 71 VP1 activates calmodulin-dependent protein kinase II and results in the rearrangement of vimentin in human astrocyte cells." in: PLoS ONE, Vol. 8, Issue 9, pp. e73900, (2013) (PubMed).

Target Details for PKA

Target: PKA (Protein Kinase A (PKA))

Alternative Name: PKA alpha + beta

Background:

Synonyms: cAMP-dependent protein kinase catalytic subunit beta, PKA C-beta, PRKACB

Background: Mediates cAMP-dependent signaling triggered by receptor binding to GPCRs. PKA activation regulates diverse cellular processes such as cell proliferation, the cell cycle, and differentiation and regulation of microtubule dynamics, chromatin condensation and decondensation, nuclear envelope disassembly and reassembly, as well as regulation of intracellular transport mechanisms and ion flux. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis (By similarity).

Gene ID: 282323

UniProt: P05131

Pathways: SARS-CoV-2 Protein Interactome