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ALPL antibody

ALPL Reactivity: Human IHC (f) Host: Mouse Monoclonal ALPL-597 unconjugated
Catalog No. ABIN6936393
  • Target See all ALPL Antibodies
    ALPL (Alkaline Phosphatase, Liver/bone/kidney (ALPL))
    Reactivity
    • 77
    • 50
    • 17
    • 5
    • 1
    • 1
    • 1
    • 1
    • 1
    Human
    Host
    • 76
    • 17
    • 1
    • 1
    Mouse
    Clonality
    • 78
    • 17
    Monoclonal
    Conjugate
    • 58
    • 9
    • 6
    • 4
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This ALPL antibody is un-conjugated
    Application
    • 68
    • 37
    • 26
    • 16
    • 13
    • 13
    • 12
    • 10
    • 10
    • 7
    • 5
    • 3
    • 2
    • 1
    • 1
    Immunohistochemistry (Formalin-fixed Sections) (IHC (f))
    Specificity
    There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific). The first three are located together on chromosome 2, while the tissue non-specific form is located on chromosome 1. The product of this gene is a membrane bound glycosylated enzyme that is not expressed in any particular tissue and is, therefore, referred to as the tissue-nonspecific form of the enzyme. The exact physiological function of the alkaline phosphatases is not known. A proposed function of this form of the enzyme is matrix mineralization, however, mice that lack a functional form of this enzyme show normal skeletal development. This enzyme has been linked directly to hypo-phosphatasia, a disorder that is characterized by hypercalcemia and includes skeletal defects.
    Cross-Reactivity (Details)
    Human. Cow.
    Purification
    1.0mg/ml of Ab purified from Bioreactor by Protein A/G.
    Immunogen
    Recombinant human ALPL protein
    Clone
    ALPL-597
    Isotype
    IgG1 kappa
    Top Product
    Discover our top product ALPL Primary Antibody
  • Application Notes

    Known_Application: Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT)(Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes)Optimal dilution for a specific application should be determined.

    Positive_Control: Intestine.

    Restrictions
    For Research Use only
  • Concentration
    1.0 mg/mL
    Buffer
    Prepared in 10 mM PBS, WITHOUT BSA and Azide.
    Preservative
    Azide free
    Storage
    -20 °C,-80 °C
    Storage Comment
    Antibody without azide store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.
    Expiry Date
    24 months
  • Target
    ALPL (Alkaline Phosphatase, Liver/bone/kidney (ALPL))
    Alternative Name
    ALPL (ALPL Products)
    Synonyms
    ALP antibody, iap antibody, alpl antibody, AP-TNAP antibody, APTNAP antibody, HOPS antibody, TNAP antibody, TNSALP antibody, Akp-2 antibody, Akp2 antibody, PHOA antibody, TNS-AP antibody, alkaline phosphatase, liver/bone/kidney L homeolog antibody, alkaline phosphatase, liver/bone/kidney antibody, alkaline phosphatase, intestinal, gene 2 antibody, alkaline phosphatase, liver/bone/kidney pseudogene antibody, alpl.L antibody, ALPL antibody, alpi.2 antibody, LOC100031702 antibody, Alpl antibody
    Background
    Alkaline phosphatase, germ cell, Alkaline phosphatase, testicular and thymus, Alkaline phosphatase liver/bone/kidney, Alkaline phosphatase, tissue-nonspecific, ALPG, ALPL, Germ cell alkaline phosphatase, Testicular and thymus alkaline phosphatase, Tissue non-specific alkaline phosphatase, Tissue nonspecific ALP (TNAP or TNSALP),Alkaline Phosphatase (Tissue-Nonspecific)
    Cellular localisation: Cell Surface
    Molecular Weight
    55kDa
    Gene ID
    249, 75431
    UniProt
    P05186
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