FUT3 antibody
-
- Target See all FUT3 Antibodies
- FUT3 (Fucosyltransferase 3 (Galactoside 3(4)-L-Fucosyltransferase, Lewis Blood Group) (FUT3))
-
Reactivity
- Human
-
Host
- Mouse
-
Clonality
- Monoclonal
-
Conjugate
- This FUT3 antibody is un-conjugated
-
Application
- Immunofluorescence (IF), Immunohistochemistry (Formalin-fixed Sections) (IHC (f))
- Specificity
- The Lewis histo-blood group system comprises a set of fucosylated glycosphingolipids that are synthesized by exocrine epithelial cells and circulate in body fluids. The glycosphingolipids function in embryogenesis, tissue differentiation, tumor metastasis, inflammation, and bacterial adhesion. They are secondarily absorbed to red blood cells giving rise to their Lewis phenotype. This gene is a member of the fucosyltransferase family, which catalyzes the addition of fucose to precursor polysaccharides in the last step of Lewis antigen biosynthesis. It encodes an enzyme with alpha(1,3)-fucosyltransferase and alpha(1,4)-fucosyltransferase activities. Lewis blood group antigens are carbohydrate moieties structurally integrated in mucous secretions. Lewis antigen system alterations have been described in gastric carcinoma and associated lesions. Anomalous expression of Lewis B antigen has been found in some non-secretory gastric carcinomas and colorectal cancers.
- Cross-Reactivity (Details)
- Human. Guinea Pig.
- Purification
- 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.
- Immunogen
- Mucin isolated from a human ovarian cyst fluid
- Clone
- SPM194
- Isotype
- IgG1 kappa
- Top Product
- Discover our top product FUT3 Primary Antibody
-
-
- Application Notes
-
Known_Application: Immunofluorescence (1-2 μg/mL), Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT)(Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes), Optimal dilution for a specific application should be determined.
Positive_Control: Colon.
- Restrictions
- For Research Use only
-
- Concentration
- 1.0 mg/mL
- Buffer
- Prepared in 10 mM PBS, WITHOUT BSA and Azide.
- Preservative
- Azide free
- Storage
- -20 °C,-80 °C
- Storage Comment
- Antibody without azide store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.
- Expiry Date
- 24 months
-
- Target
- FUT3 (Fucosyltransferase 3 (Galactoside 3(4)-L-Fucosyltransferase, Lewis Blood Group) (FUT3))
- Alternative Name
- FUT3 (FUT3 Products)
- Synonyms
- CD174 antibody, FT3B antibody, FucT-III antibody, LE antibody, Les antibody, fut356 antibody, FUT3 antibody, ATFUT3 antibody, F1M20.10 antibody, F1M20_10 antibody, fucosyltransferase 3 antibody, fucosyltransferase 3 (Lewis blood group) antibody, fucosyltransferase 3 (Lewis blood group) L homeolog antibody, fucosyltransferase 3 (galactoside 3(4)-L-fucosyltransferase, Lewis blood group) antibody, fucosyltransferase 3 antibody, galactoside 3(4)-L-fucosyltransferase antibody, FUT3 antibody, fut3.L antibody, fut3 antibody, LOC697452 antibody, LOC697582 antibody
- Background
-
Blood group Lewis alpha-4-fucosyltransferase, Fucosyltransferase 3, Fucosyltransferase III, FucT-III, FUT3, Galactoside 3(4)-L-fucosyltransferase, gastric mucin, leB, lewis antigen system, lewis B blood group antigen, Lewis FT, major airway glycoprotein,Blood Group Antigen Lewis B
Cellular localisation: Cytoplasmic - Molecular Weight
- 45kDa
- Gene ID
- 2525, 169238
- UniProt
- P21217
-