LSP1 antibody (AA 174-278)
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- Target See all LSP1 Antibodies
- LSP1 (Lymphocyte-Specific Protein 1 (LSP1))
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Binding Specificity
- AA 174-278
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Reactivity
- Human
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Host
- Mouse
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Clonality
- Monoclonal
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Conjugate
- This LSP1 antibody is un-conjugated
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Application
- ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Coating (Coat)
- Specificity
- LSP1 is a hematopoietic-expressed gene that encodes an F-actin-binding, leukocyte-specific (including B and T lymphocytes, granulocytes and macrophages), phosphoprotein. However, mRNA splice variants that do not encode the lympho-specific protein are expressed from this gene in nonlymphoid cell lines as well (myocytes, stromal cells and fibroblasts), suggesting pp52 has a divergent role in signal transduction. The pp52 (LSP1) locus maps to human chromosome 11p15.5, which is implicated in tumor-related chromosomal translocations found in chronic lymphocytic leukemia. The pp52 promoter contains key elements that control transcriptional activity including an initiator specifying the unique 5' terminus of pp52 mRNA, tandem pairs of Ets and SP1 motifs, and a single C/EBP motif. LSP1 binds the cytoskeleton and has been implicated in affecting cytoskeletal remodeling in a variety of leukocyte functions, including cell motility and chemotaxis.
- Cross-Reactivity (Details)
- Human.
- Purification
- 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.
- Immunogen
- Recombinant fragment of human LSP1 protein (around aa174-278) (exact sequence is proprietary)
- Clone
- LSP1-3042
- Isotype
- IgG1 kappa
- Top Product
- Discover our top product LSP1 Primary Antibody
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- Application Notes
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Known_Application: ELISA (For coating, order antibody without BSA); Optimal dilution for a specific application should be determined.
Positive_Control: Human tonsil, colon, spleen or Hodgkin's lymphoma (IHC-P).
- Restrictions
- For Research Use only
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- Concentration
- 1.0 mg/mL
- Buffer
- Prepared in 10 mM PBS, WITHOUT BSA and Azide.
- Preservative
- Azide free
- Storage
- -20 °C,-80 °C
- Storage Comment
- Antibody without azide store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.
- Expiry Date
- 24 months
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- Target
- LSP1 (Lymphocyte-Specific Protein 1 (LSP1))
- Alternative Name
- LSP1 (LSP1 Products)
- Synonyms
- LSP1 antibody, Lsp-1 antibody, WP34 antibody, p50 antibody, pp52 antibody, lymphocyte-specific protein 1 antibody, lymphocyte-specific protein 1 L homeolog antibody, lymphocyte specific 1 antibody, LSP1 antibody, lsp1.L antibody, Lsp1 antibody
- Background
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WP34, pp52, lymphocyte specific protein 1, leukocyte specific protein 1,Lymphocyte Specific Protein 1 (LSP1) / pp52
Cellular localisation: Membrane. - Molecular Weight
- 52kDa
- Gene ID
- 4046, 56729
- UniProt
- P33241
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