PDCD1LG2 antibody (AA 27-220)
-
- Target See all PDCD1LG2 Antibodies
- PDCD1LG2 (Programmed Cell Death 1 Ligand 2 (PDCD1LG2))
-
Binding Specificity
- AA 27-220
-
Reactivity
- Human
-
Host
- Mouse
-
Clonality
- Monoclonal
-
Conjugate
- This PDCD1LG2 antibody is un-conjugated
-
Application
- Flow Cytometry (FACS)
- Specificity
- Recognizes a protein of about 31 kDa, which is identified as PD-L2 (same as PDCD1LG2). Engagement of CD28 by B7-1 (CD80) or B7-2 (CD86) in the presence of antigen promotes T cell proliferation, cytokine production, differentiation of effector T cells and the induction of Bcl-x, a promoter of T cell survival. Conversely, engagement of CTLA4 by B7-1 or B7-2 may inhibit proliferation and IL-2 production. PD-L2 does not bind CD28, cytotoxic T lymphocyte A4 or ICOS (inducible co-stimulator). The constitutive expression of PD-L1 and PD-L2 on parenchymal cells of heart, lung and kidney suggests that the Pdcd-1-Pdcd-L system could provide unique negative signaling to help prevent autoimmune disease.
- Cross-Reactivity (Details)
- Human.
- Purification
- 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.
- Immunogen
- Recombinant fragment (around aa 27-220) of human PD-L2 protein (exact sequence is proprietary)
- Clone
- PDL2-1850
- Isotype
- IgG1 kappa
- Top Product
- Discover our top product PDCD1LG2 Primary Antibody
-
-
- Application Notes
-
Known_Application: Flow Cytometry (1-2 μg/million cells),Optimal dilution for a specific application should be determined.
Positive_Control: Placenta or Pancreas. Thyroid Carcinoma.
- Restrictions
- For Research Use only
-
- Concentration
- 1.0 mg/mL
- Buffer
- Prepared in 10 mM PBS, WITHOUT BSA and Azide.
- Preservative
- Azide free
- Storage
- -20 °C,-80 °C
- Storage Comment
- Antibody without azide store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.
- Expiry Date
- 24 months
-
- Target
- PDCD1LG2 (Programmed Cell Death 1 Ligand 2 (PDCD1LG2))
- Alternative Name
- PDCD1LG2 (PDCD1LG2 Products)
- Synonyms
- PDL2 antibody, B7DC antibody, Btdc antibody, CD273 antibody, PD-L2 antibody, PDCD1L2 antibody, bA574F11.2 antibody, B7-DC antibody, F730015O22Rik antibody, programmed cell death 1 ligand 2 antibody, PDCD1LG2 antibody, Pdcd1lg2 antibody
- Background
-
B7 dendritic cell molecule, B7-DC, B7DC, Btdc, Butyrophilin B7DC, CD273, PD-L2, PDCD1L2, PDCD1LG2, PDL2, Programmed death ligand 2,PD-L2 / PDCD1LG2 / CD273
Cellular localisation: Cytoplasmic and Cell Surface - Molecular Weight
- 31kDa
- Gene ID
- 80380, 532279, 617872
-