TNFSF9 antibody
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- Target See all TNFSF9 Antibodies
- TNFSF9 (Tumor Necrosis Factor (Ligand) Superfamily, Member 9 (TNFSF9))
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Reactivity
- Human
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Host
- Mouse
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Clonality
- Monoclonal
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Conjugate
- This TNFSF9 antibody is un-conjugated
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Application
- Flow Cytometry (FACS), Immunohistochemistry (Formalin-fixed Sections) (IHC (f))
- Specificity
- TNFSF9 / 4-1BBL is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This transmembrane cytokine is a bidirectional signal transducer that acts as a ligand for TNFRSF9 / 4-1BB, which is a costimulatory receptor molecule in T lymphocytes. This cytokine and its receptor are involved in the antigen presentation process and in the generation of cytotoxic T cells. The receptor TNFRSF9 / 4-1BB is absent from resting T lymphocytes but rapidly expressed upon antigenic stimulation. It has been shown to reactivate anergic T lymphocytes in addition to promoting T lymphocyte proliferation. This cytokine is required for the optimal CD8 responses in CD8 T cells. This cytokine is expressed in carcinoma cell lines, and is thought to be involved in T cell-tumor cell interaction.
- Cross-Reactivity (Details)
- Human.
- Purification
- 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.
- Immunogen
- Recombinant full-length human CD137L protein
- Clone
- CD137L-1547
- Isotype
- IgG2a kappa
- Top Product
- Discover our top product TNFSF9 Primary Antibody
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- Application Notes
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Known_Application: Flow Cytometry (1-2 μg/million cells in 0.1ml), Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT)(Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes)Optimal dilution for a specific application should be determined.
Positive_Control: Raji, 293T, HEK293 cells. Kidney.
- Restrictions
- For Research Use only
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- Concentration
- 1.0 mg/mL
- Buffer
- Prepared in 10 mM PBS, WITHOUT BSA and Azide.
- Preservative
- Azide free
- Storage
- -20 °C,-80 °C
- Storage Comment
- Antibody without azide store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.
- Expiry Date
- 24 months
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- Target
- TNFSF9 (Tumor Necrosis Factor (Ligand) Superfamily, Member 9 (TNFSF9))
- Alternative Name
- TNFSF9 (TNFSF9 Products)
- Synonyms
- TNFSF9 antibody, 4-1BB-L antibody, 4-1BBL antibody, AI848817 antibody, Cd137l antibody, Ly63l antibody, CD137L antibody, TNF superfamily member 9 antibody, tumor necrosis factor (ligand) superfamily, member 9 antibody, Tnfsf9 antibody, LOC476729 antibody, TNFSF9 antibody
- Background
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4-1BB ligand, 4-1BBL, CD137L, ILA ligand (TNF related), Ly63l, Tumor necrosis factor ligand 5A (TNLG5A), Tumor necrosis factor ligand superfamily member 9 (TNFSF9),CD137L / 4-1BBL / TNFSF9
Cellular localisation: Cell Surface and Cytoplasmic - Molecular Weight
- 27kDa
- Gene ID
- 8744, 1524
- UniProt
- P41273
- Pathways
- Activated T Cell Proliferation, Cancer Immune Checkpoints
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