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HLA-DRA antibody

HLA-DRA Reactivity: Human IHC, FACS, IF, StM Host: Mouse Monoclonal 19-26-1-same as MB-26-1 unconjugated
Catalog No. ABIN6939638
  • Target See all HLA-DRA Antibodies
    HLA-DRA (HLA Class II DR alpha (HLA-DRA))
    Reactivity
    • 89
    • 17
    • 10
    • 10
    • 9
    • 9
    • 3
    • 2
    • 2
    • 1
    Human
    Host
    • 57
    • 47
    • 1
    • 1
    Mouse
    Clonality
    • 57
    • 49
    Monoclonal
    Conjugate
    • 54
    • 12
    • 5
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    This HLA-DRA antibody is un-conjugated
    Application
    • 49
    • 48
    • 34
    • 32
    • 18
    • 12
    • 11
    • 10
    • 9
    • 5
    • 3
    • 3
    • 1
    • 1
    Immunohistochemistry (IHC), Flow Cytometry (FACS), Immunofluorescence (IF), Staining Methods (StM)
    Specificity
    This MAb reacts with the HLA-DR antigen, a member of MHC class II molecules. It does not cross react with HLA-DP and HLA-DQ. HLA-DR is a heterodimeric cell surface glycoprotein comprised of a 36 kDa alpha (heavy) chain and a 28 kDa beta (light) chain. It is expressed on B-cells, activated T-cells, monocytes/macrophages, dendritic cells and other non-professional APCs. In conjunction with the CD3/TCR complex and CD4 Molecules, HLA-DR is critical for efficient peptide presentation to CD4+ T cells. It is an excellent histiocytic marker in paraffin sections producing intense cytoplasmic staining. True histiocytic neoplasms are similarly positive. HLA-DR antigens also occur on a variety of epithelial cells and their corresponding neoplastic counterparts.
    Purification
    Purified by Protein A/G
    Immunogen
    Raji cells
    Clone
    19-26-1-same as MB-26-1
    Isotype
    IgG2a kappa
    Top Product
    Discover our top product HLA-DRA Primary Antibody
  • Application Notes

    Positive Control: Raji, Ramos, Daudi or HuT78 cells. Tonsil or lymph node.

    Known Application: Flow Cytometry (1-2 μg/million cells), Immunofluorescence (1-2 μg/mL), Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT)(Staining of formalin-fixed tissues requires boiling tissue sections in 10 mM Citrate Buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes), Optimal dilution for a specific application should be determined.

    Restrictions
    For Research Use only
  • Concentration
    200 μg/mL
    Buffer
    10 mM PBS with 0.05 % BSA & 0.05 % azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C,-80 °C
    Storage Comment
    Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
    Expiry Date
    24 months
  • Target
    HLA-DRA (HLA Class II DR alpha (HLA-DRA))
    Alternative Name
    HLA-DRA (HLA-DRA Products)
    Synonyms
    HLA-DRA1 antibody, MLRW antibody, DR-alpha antibody, HLA-DRA antibody, Mamu-DRA1 antibody, major histocompatibility complex, class II, DR alpha L homeolog antibody, major histocompatibility complex, class II, DR alpha antibody, hla-dra.L antibody, HLA-DRA antibody, MAMU-DRA antibody, BOLA-DRA antibody
    Molecular Weight
    36kDa (α, chain) and 27kDa (β, chain)
    Gene ID
    3122
    UniProt
    P01903
    Pathways
    TCR Signaling, CXCR4-mediated Signaling Events
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