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Insulin Receptor antibody (Extracellular Domain)

This anti-Insulin Receptor antibody is a Mouse Monoclonal antibody detecting Insulin Receptor in ELISA and Coat. Suitable for Human.
Catalog No. ABIN6939799

Quick Overview for Insulin Receptor antibody (Extracellular Domain) (ABIN6939799)

Target

See all Insulin Receptor (INSR) Antibodies
Insulin Receptor (INSR)

Reactivity

  • 175
  • 92
  • 82
  • 16
  • 13
  • 8
  • 7
  • 6
  • 6
  • 6
  • 4
  • 3
  • 2
  • 2
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  • 1
  • 1
  • 1
  • 1
  • 1
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Human

Host

  • 165
  • 30
  • 2
  • 1
Mouse

Clonality

  • 151
  • 47
Monoclonal

Conjugate

  • 128
  • 17
  • 15
  • 5
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  • 2
  • 2
  • 2
  • 2
  • 2
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  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
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  • 1
This Insulin Receptor antibody is un-conjugated

Application

  • 146
  • 77
  • 63
  • 36
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  • 15
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  • 4
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  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
ELISA, Coating (Coat)

Clone

INSR-1661
  • Binding Specificity

    • 16
    • 14
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    • 10
    • 8
    • 8
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    • 5
    • 5
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    • 4
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    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Extracellular Domain

    Purification

    Purified by Protein A/G

    Immunogen

    Recombinant fragment of extracellular domain of human Insulin Receptor alpha (exact sequence is proprietary)

    Isotype

    IgG1 kappa
  • Application Notes

    Positive Control: Jurkat cells. Human pancreas.

    Known Application: ELISA (Use Ab at 2-4 μg/mL for coating) (Order Ab without BSA)Optimal dilution for a specific application should be determined.

    Restrictions

    For Research Use only
  • Concentration

    200 μg/mL

    Buffer

    10 mM PBS with 0.05 % BSA & 0.05 % azide.

    Preservative

    Sodium azide

    Precaution of Use

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Storage

    4 °C,-80 °C

    Storage Comment

    Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

    Expiry Date

    24 months
  • Target

    Insulin Receptor (INSR)

    Alternative Name

    INSR

    Background

    The insulin receptor (INSR) is a heterodimeric protein complex that has an intracellular subunit, which is disulfide-linked to a transmembrane segment. The insulin ligand binds to the INSR and initiates molecular signaling pathways that promote glucose uptake in cells and glycogen synthesis. Insulin binding to INSR induces phosphorylation of intra-cellular tyrosine kinase domains and recruitment of multiple SH2 and SH3 domain-containing intracellular proteins that serve as signaling intermediates for pleiotropic effects of insulin. Type 1 diabetes is an autoimmune condition of the endocrine pancreas that results in destruction of insulin secreting cells and a progressive loss in insulin-sensitive glucose uptake by cells.

    Molecular Weight

    135kDa

    Gene ID

    3643

    UniProt

    P06213

    Pathways

    NF-kappaB Signaling, RTK Signaling, AMPK Signaling, Carbohydrate Homeostasis, Regulation of Cell Size, Regulation of Carbohydrate Metabolic Process, Growth Factor Binding, Negative Regulation of Transporter Activity
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