Insulin Receptor antibody (Extracellular Domain)

Catalog No. ABIN6939799

This anti-Insulin Receptor antibody is a Mouse Monoclonal antibody detecting Insulin Receptor in ELISA and Coat. Suitable for Human.

Quick Overview for Insulin Receptor antibody (Extracellular Domain) (ABIN6939799)

Target: Insulin Receptor (INSR)

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This Insulin Receptor antibody is un-conjugated

Application: ELISA, Coating (Coat)

Clone: INSR-1661

Product Details anti-Insulin Receptor Antibody

Binding Specificity: Extracellular Domain

Purification: Purified by Protein A/G

Immunogen: Recombinant fragment of extracellular domain of human Insulin Receptor alpha (exact sequence is proprietary)

Isotype: IgG1 kappa

Application Details

Application Notes:

Positive Control: Jurkat cells. Human pancreas.

Known Application: ELISA (Use Ab at 2-4 μg/mL for coating) (Order Ab without BSA)Optimal dilution for a specific application should be determined.

Restrictions: For Research Use only

Handling

Concentration: 200 μg/mL

Buffer: 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-80 °C

Storage Comment: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Expiry Date: 24 months

Target Details for Insulin Receptor

Target: Insulin Receptor (INSR)

Alternative Name: INSR

Background: The insulin receptor (INSR) is a heterodimeric protein complex that has an intracellular subunit, which is disulfide-linked to a transmembrane segment. The insulin ligand binds to the INSR and initiates molecular signaling pathways that promote glucose uptake in cells and glycogen synthesis. Insulin binding to INSR induces phosphorylation of intra-cellular tyrosine kinase domains and recruitment of multiple SH2 and SH3 domain-containing intracellular proteins that serve as signaling intermediates for pleiotropic effects of insulin. Type 1 diabetes is an autoimmune condition of the endocrine pancreas that results in destruction of insulin secreting cells and a progressive loss in insulin-sensitive glucose uptake by cells.

Molecular Weight: 135kDa

Gene ID: 3643

UniProt: P06213

Pathways: NF-kappaB Signaling, RTK Signaling, AMPK Signaling, Carbohydrate Homeostasis, Regulation of Cell Size, Regulation of Carbohydrate Metabolic Process, Growth Factor Binding, Negative Regulation of Transporter Activity