SDHB antibody (AA 165-273)

Catalog No. ABIN6940566

This Mouse Monoclonal antibody specifically detects SDHB in WB. It exhibits reactivity toward Human.

Quick Overview for SDHB antibody (AA 165-273) (ABIN6940566)

Target: SDHB (Succinate Dehydrogenase Complex, Subunit B, Iron Sulfur (Ip) (SDHB))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This SDHB antibody is un-conjugated

Application: Western Blotting (WB)

Clone: SDHB-2382

Product Details anti-SDHB Antibody

Binding Specificity: AA 165-273

Purification: Purified by Protein A/G

Immunogen: Recombinant fragment (around aa 165-273) of human SDHB protein (exact sequence is proprietary)

Isotype: IgG2b kappa

Application Details

Application Notes:

Positive Control: Jurkat or HepG2 cells. Human kidney or liver.

Known Application: Western Blot (0.5-1.0 μg/mL), Optimal dilution for a specific application should be determined.

Restrictions: For Research Use only

Handling

Concentration: 200 μg/mL

Buffer: 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-80 °C

Storage Comment: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Expiry Date: 24 months

Target Details for SDHB

Target: SDHB (Succinate Dehydrogenase Complex, Subunit B, Iron Sulfur (Ip) (SDHB))

Alternative Name: SDHB

Background: Succinate dehydrogenase (SDH) is Complex II in the mitochondria, vital for mitochondrial electron transport, as well as Krebs cycle function.Four subunits comprise the SDH protein complex: a flavochrome subunit (SDHA), an iron-sulfur protein (SDHB) and two membrane-bound subunits (SDHC and SDHD) anchored to the inner mitochondrial membrane. The SDH complex functions as a tumor suppressor. Loss of any subunit proteins lead to destabilization of the complex and tumor formation.Antibody to SDHB is helpful in the identification of phaeochromocytomas, paragangliomas and GIST.

Molecular Weight: 32kDa

Gene ID: 6390

UniProt: P21912