CD11b antibody

Catalog No. ABIN6942386

The Rabbit Monoclonal anti-CD11b antibody (Clone 9B3) (ABIN6942386) specifically detects CD11b in WB, IHC (fro), IHC (p) and IF (p). The antibody is reactive with Human samples.

Quick Overview for CD11b antibody (ABIN6942386)

Target: CD11b (ITGAM) (Integrin alpha M (ITGAM))

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This CD11b antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Clone: 9B3

Product Details anti-CD11b Antibody

Purpose: CD11b Monoclonal Antibody

Cross-Reactivity: Human

Purification: Purified by Protein A.

Immunogen: Recombinant Human ITGAM

Isotype: IgG

Application Details

Application Notes: WB(WB(1:1000-2000)), IHC-P(IHC-P(1:200-800)), IHC-F(IHC-F(1:200-800)), IF(IHC-P)(IF(IHC-P)(1:200-800))

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4C. Store at -20C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

Target Details for CD11b

Target: CD11b (ITGAM) (Integrin alpha M (ITGAM))

Alternative Name: CD11b

Background:

Synonyms: Antigen CD11b (p170), CD11 antigen like family member B, CD11 antigen like family member C, Cell surface glycoprotein MAC 1 subunit alpha, CR 3 alpha chain, CR3A, Integrin alpha M, Integrin alpha X, Integrin, alpha M (complement component 3 receptor 3 subunit), Integrin, alpha X (antigen CD11C (p150), alpha polypeptide), Integrin, alpha X (complement component 3 receptor 4 subunit), ITGAM, ITGAX, Leu M5, alpha subunit, Leukocyte adhesion glycoprotein p150,95 alpha chain, Leukocyte adhesion receptor MO1, Leukocyte adhesion receptor p150,95, Leukocyte surface antigen p150,95, alpha subunit, MAC1A, Macrophage antigen alpha polypeptide, MO1A, Myeloid membrane antigen, alpha subunit, Neutrophil adherence receptor alpha M subunit, p150 95 integrin alpha chain, SLEB6, ITAM_HUMAN, c equivalent, Integrin αM.

Background: This gene encodes the integrin alpha M chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as macrophage receptor 1 ('Mac-1'), or inactivated-C3b (iC3b) receptor 3 ('CR3'). The alpha M beta 2 integrin is important in the adherence of neutrophils and monocytes to stimulated endothelium, and also in the phagocytosis of complement coated particles. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]

Gene ID: 3684

UniProt: P11215

Pathways: Apoptosis, Activation of Innate immune Response, Toll-Like Receptors Cascades, Activated T Cell Proliferation