CRMP1 antibody

Catalog No. ABIN6942686

Product Details anti-CRMP1 Antibody

Target: CRMP1 (Collapsin Response Mediator Protein 1 (CRMP1))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Monoclonal

Conjugate: This CRMP1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Flow Cytometry (FACS)

Cross-Reactivity: Human, Mouse, Rat

Purification: Purified by Protein A.

Immunogen: Recombinant protein within human CRMP1 aa 400 to the C-terminus

Clone: 6C5

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
FCM 1:20-100
IHC-P 1:200-400
IF(IHC-P) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 1xTBS ( pH 7.4), 1 % BSA, 40 %Glycerol and 0.05 % Sodium Azide.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C for up to 2 weeks. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Expiry Date: 12 months

Target Details for CRMP1

Target: CRMP1 (Collapsin Response Mediator Protein 1 (CRMP1))

Alternative Name: CRMP1 (CRMP1 Products)

Synonyms: CRMP1 antibody, crmp1 antibody, MGC145930 antibody, CRMP 1 antibody, CRMP-1 antibody, PCRMP 1 antibody, PCRMP-1 antibody, PCRMP1 antibody, PfCRMP-1 antibody, DPYSL1 antibody, DRP-1 antibody, DRP1 antibody, ULIP-3 antibody, Dpysl1 antibody, Ulip3 antibody, CRMP1B antibody, collapsin response mediator protein 1 antibody, dihydropyrimidinase-related protein 1 antibody, cysteine repeat modular protein 1, putative antibody, collapsin response mediator protein 1 L homeolog antibody, CRMP1 antibody, crmp1 antibody, LOC100350067 antibody, PfCRMP1 antibody, Crmp1 antibody, crmp1.L antibody

Background:

Synonyms: Dihydropyrimidinase-related protein 1, Collapsin response mediator protein 1, Unc-33-like phosphoprotein 3, CRMP-1, ULIP-3, CRMP1, DPYSL1, ULIP3.

Background: Collapsin response mediator proteins (CRMPs), including CRMP-1 (DRP-1), CRMP-2 (DRP-2 or TOAD64), CRMP-3 (DRP-4), CRMP-4 (DRP-3) and CRMP-5 (DRP-5), mediate signal transduction after exposure of neural cells to the axon guidance molecule Semaphorin 3A (SEMA3A)/collapsin. CRMPs are present in the developing cerebral cortex and neocortical neurons and are responsive to SEMA3A. In the adult brain, the expression of CRMPs is dramatically downregulated. However, they remain expressed in structures that retain their capacity for differentiation and plasticity. CRMP-1 is also involved in cancer invasion and metastasis. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. CRMP-1 plays a role in axon guidance, invasive growth and cell migration. CRMP-1 may participate in cytokinesis.

Gene ID: 1400

UniProt: Q14194