DDX6 antibody

Catalog No. ABIN6942821

Product Details anti-DDX6 Antibody

Target: DDX6 (DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 6 (DDX6))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Monoclonal

Conjugate: This DDX6 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Cross-Reactivity: Human, Mouse, Rat

Purification: Purified by Protein A.

Immunogen: Recombinant protein within human DDX6 aa 100-300

Clone: 15C2

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
IHC-P 1:200-400

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 1xTBS ( pH 7.4), 1 % BSA, 40 %Glycerol and 0.05 % Sodium Azide.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C for up to 2 weeks. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Expiry Date: 12 months

Target Details for DDX6

Target: DDX6 (DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 6 (DDX6))

Alternative Name: DDX6 (DDX6 Products)

Synonyms: si:ch211-147p17.1 antibody, P54H antibody, Xp54 antibody, hlr2 antibody, me31b antibody, p54 antibody, rck antibody, HLR2 antibody, P54 antibody, RCK antibody, p54h antibody, RGD1564560 antibody, 1110001P04Rik antibody, E230023J21Rik antibody, mRCK/P54 antibody, DEAD-box helicase 6 antibody, DEAD (Asp-Glu-Ala-Asp) box helicase 6 antibody, DEAD-box helicase 6 L homeolog antibody, DEAD (Asp-Glu-Ala-Asp) box polypeptide 6 antibody, DDX6 antibody, ddx6 antibody, ddx6.L antibody, Ddx6 antibody

Background:

Synonyms: Probable ATP-dependent RNA helicase DDX6, ATP-dependent RNA helicase p54, DEAD box protein 6, Oncogene RCK, DDX6, HLR2, RCK.

Background: RCK, also known as DDX6 and P54, is a member of the DEAD-box RNA helicase family of proteins, all of which share common protein motifs. Found in most tissues, RCK is an unwindase that exhibits ATP-dependent RNA un-winding activity, as well as the ability to decay RNA in the 5'-3' direction. In non-malignant cells, RCK is associated with all processes of normal RNA metabolism including splicing, export and translation initiation. Mutations in the gene encoding RCK can cause the protein to be overexpressed, changing its function to that of an oncogene that positively regulates the expression of genes involved in cell growth and proliferation. It is believed that, through its unwindase activity, the main function of RCK is to downregulate mRNA expression and maintain normal transcriptional levels within the cell.

Gene ID: 1656

UniProt: P26196

Pathways: Ribonucleoprotein Complex Subunit Organization