Protein Kinase, CAMP-Dependent, Regulatory, Type II, beta (PRKAR2B) antibody

Details for Product No. ABIN6944655
Target
Reactivity
Human, Mouse, Rat
66
31
22
3
2
1
Host
Rabbit
64
2
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
5
4
4
4
4
4
1
1
1
1
1
1
Application
Flow Cytometry (FACS), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
61
43
13
9
3
2
2
1
1
1
Options
Immunogen N terminal human PRKAR2B
Clone 5G1
Isotype IgG
Purification Purified by Protein A.
Target
Alternative Name PRKAR2B (PRKAR2B Antibody Abstract)
Background

PRKAR2B is a regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. Type II regulatory chains mediate membrane association by binding to anchoring proteins, including the MAP2 kinase. This subunit can be phosphorylated by the activated catalytic subunit. This subunit has been shown to interact with and suppress the transcriptional activity of the cAMP responsive element binding protein 1 (CREB1) in activated T cells. Knockout studies in mice suggest that this subunit may play an important role in regulating energy balance and adiposity. The studies also suggest that this subunit may mediate the gene induction and cataleptic behavior induced by haloperidol.

Subcellular location: Cytoplasm, Cell membrane


Synonyms: cAMP-dependent protein kinase type II-beta regulatory subunit, PRKAR2B, protein kinase cAMP-dependent type II regulatory subunit beta, PRKAR2, RII-BETA
Gene ID 5577
UniProt P31323
Pathways Hedgehog Signaling, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Myometrial Relaxation and Contraction, M Phase, G-protein mediated Events, Interaction of EGFR with phospholipase C-gamma, SARS-CoV-2 Protein Interactome, The Global Phosphorylation Landscape of SARS-CoV-2 Infection
Application Notes FCM(1:50-100), IHC-P(1:50-200), IF(IHC-P)(1:50-200), IF(ICC)(1:50-200)
Restrictions For Research Use only
Concentration 1 μg/μL
Buffer Aqueous buffered solution containing 1xTBS ( pH 7.4), 1 % BSA, 40 %Glycerol and 0.05 % Sodium Azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Expiry Date 12 months