SMC1A antibody (pSer957)
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- Target See all SMC1A Antibodies
- SMC1A (Structural Maintenance of Chromosomes 1A (SMC1A))
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Binding Specificity
- pSer957
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Reactivity
- Human
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Host
- Rabbit
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Clonality
- Monoclonal
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Conjugate
- This SMC1A antibody is un-conjugated
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Application
- Western Blotting (WB), Immunohistochemistry (IHC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc))
- Cross-Reactivity
- Human
- Purification
- Purified by Protein A.
- Immunogen
- Synthetic phospho-peptide corresponding to residues surrounding Ser957 of human SMC1
- Clone
- 8H5
- Isotype
- IgG
- Top Product
- Discover our top product SMC1A Primary Antibody
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- Application Notes
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WB 1:300-5000
IHC-P 1:200-400
IF(ICC) 1:50-200
IHC() - Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 μg/μL
- Buffer
- Aqueous buffered solution containing 1xTBS ( pH 7.4), 1 % BSA, 40 %Glycerol and 0.05 % Sodium Azide.
- Preservative
- ProClin
- Precaution of Use
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- Storage
- -20 °C
- Storage Comment
- Store at -20°C for 12 months.
- Expiry Date
- 12 months
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- Target
- SMC1A (Structural Maintenance of Chromosomes 1A (SMC1A))
- Alternative Name
- SMC1 (SMC1A Products)
- Synonyms
- CDLS2 antibody, DXS423E antibody, SB1.8 antibody, SMC1 antibody, SMC1L1 antibody, SMC1alpha antibody, SMCB antibody, SMC-1A antibody, NV15570 antibody, 5830426I24Rik antibody, Sb1.8 antibody, Smc1 antibody, Smc1alpha antibody, Smc1l1 antibody, Smcb antibody, mKIAA0178 antibody, smc1 antibody, smc1a antibody, smc1l1 antibody, xSMC1 antibody, smc1aa antibody, structural maintenance of chromosomes 1A antibody, structural maintenance of chromosomes 1A b antibody, structural maintenance of chromosomes 1A L homeolog antibody, SMC1A antibody, smc1a antibody, Smc1a antibody, smc1ab antibody, smc1a.L antibody
- Background
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Synonyms: Structural maintenance of chromosomes protein 1A, Sb1.8, Structural maintenance of chromosomes protein 1B, SMC protein 1A, SMC-1-alpha, SMC-1A, SMC1A, SMC protein 1B, SMC-1-beta, SMC-1B, SMC1B
Background: Involved in chromosome cohesion during cell cycle and in DNA repair. Central component of cohesin complex. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis. Involved in DNA repair via its interaction with BRCA1 and its related phosphorylation by ATM, or via its phosphorylation by ATR. Works as a downstream effector both in the ATM/NBS1 branch and in the ATR/MSH2 branch of S-phase checkpoint.
- Gene ID
- 8243
- UniProt
- Q14683
- Pathways
- Stem Cell Maintenance
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