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Transferrin Receptor 2 antibody

TFR2 Reactivity: Human WB, IHC (p) Host: Rabbit Monoclonal 1G4 unconjugated
Catalog No. ABIN6945145
  • Target See all Transferrin Receptor 2 (TFR2) Antibodies
    Transferrin Receptor 2 (TFR2)
    Reactivity
    • 30
    • 11
    • 7
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Human
    Host
    • 33
    • 6
    Rabbit
    Clonality
    • 26
    • 13
    Monoclonal
    Conjugate
    • 24
    • 6
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This Transferrin Receptor 2 antibody is un-conjugated
    Application
    • 27
    • 21
    • 9
    • 8
    • 7
    • 6
    • 3
    • 3
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Cross-Reactivity
    Human
    Purification
    Purified by Protein A.
    Immunogen
    Recombinant protein within human Transferrin Receptor 2 aa 100-300.
    Clone
    1G4
    Isotype
    IgG
    Top Product
    Discover our top product TFR2 Primary Antibody
  • Application Notes
    WB 1:300-5000
    IHC-P 1:200-400
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 1xTBS ( pH 7.4), 1 % BSA, 40 %Glycerol and 0.05 % Sodium Azide.
    Preservative
    ProClin
    Precaution of Use
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Storage
    4 °C,-20 °C
    Storage Comment
    Store at 4°C for up to 2 weeks. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
    Expiry Date
    12 months
  • Target
    Transferrin Receptor 2 (TFR2)
    Alternative Name
    TFR2 (TFR2 Products)
    Synonyms
    TFR2 antibody, Trfr2 antibody, HFE3 antibody, TFRC2 antibody, zgc:123043 antibody, transferrin receptor 2 antibody, TFR2 antibody, Tfr2 antibody, tfr2 antibody
    Background

    Synonyms: Transferrin receptor protein 2, TFR2, HFE3

    Background: Iron is a vital molecule for living organisms because it is involved in a wide variety of metabolic processes, such as oxygen transport, DNA synthesis and electron transport. Excessive iron uptake leads to tissue damage as a result of formation of free radicals. Iron uptake and storage is tightly regulated by the feedback system of iron responsive element-containing gene products and iron regulatory proteins that modulate the expression levels of the genes involved in iron metabolism. The transferrin receptor 2 (TFR2) mediates the uptake of transferrin-bound iron. It is involved in iron metabolism, hepatocyte function and erythrocyte differentiation, and is highly expressed as a protein in liver as well as in hepatocytes and erythroid precursors. The gene encoding human TRF2 maps to chromosome 7q22 and is expressed as an a isoform, which encodes a transmembrane protein, and a b isoform, which encodes a shorter, intracellular protein. Mutations in the TFR2 gene result in hereditary hemochromatosis type III (HFE3), an iron overloading disorder that results in clinical complications, including cirrhosis, cardiopathy, diabetes, endocrine dysfunctions, arthropathy and susceptibility to liver cancer.

    Gene ID
    7036
    UniProt
    Q9UP52
    Pathways
    Transition Metal Ion Homeostasis
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