NK-1.1/CD161c antibody
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- Target See all NK-1.1/CD161c products
- NK-1.1/CD161c (NK-1.1)
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Reactivity
- Mouse
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Host
- Mouse
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Clonality
- Monoclonal
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Conjugate
- This NK-1.1/CD161c antibody is un-conjugated
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Application
- Flow Cytometry (FACS), Immunoprecipitation (IP), Immunofluorescence (IF), Functional Studies (Func), Immunohistochemistry (Frozen Sections) (IHC (fro))
- Purification
- This monoclonal antibody preparation was purified from tissue culture supernatant via affinity chromatography. For In Vivo Ready™ (IVR) products, each preparation is also evaluated for endotoxin levels using the LAL assay. It is recommended to store the product undiluted at 4°C. Do not freeze.
- Endotoxin Level
- Low endotoxin: < 0.01 EU/ug
- Clone
- PK136
- Isotype
- IgG2a kappa
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- Application Notes
- This purified format is guaranteed to be >90 % pure as determined by SDS-PAGE analysis.
- Comment
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2 mg/mL
- Restrictions
- For Research Use only
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- Buffer
- 10 mM NaH2PO4, 150 mM NaCl, pH 7.2
- Preservative
- Azide free
- Storage
- 4 °C
- Storage Comment
- 2-8°C
- Expiry Date
- 12 months
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- Target
- NK-1.1/CD161c (NK-1.1)
- Alternative Name
- NK1.1 (CD161) (NK-1.1/CD161c Products)
- Synonyms
- AI462337 antibody, CD161 antibody, Ly-59 antibody, Ly55c antibody, Ly59 antibody, NK-RP1 antibody, NK1.1 antibody, NKR-P1.9 antibody, NKRP1 antibody, NKRP140 antibody, Nk-1 antibody, Nk-1.2 antibody, Nk1 antibody, Nk1.2 antibody, Nkrp1c antibody, ly-55c antibody, killer cell lectin-like receptor subfamily B member 1C antibody, Klrb1c antibody
- Background
- The PK136 antibody is specific for mouse NK1.1, a type II transmembrane lectin-like receptor and member of the killer cell lectin-like receptor (KLR) family. NK1.1 is prominently expressed on natural killer (NK) cells, and is correlated with NK cytotoxic effects toward virus-infected cells and tumor cells. NK1.1 is expressed on subsets of NKT cells in certain mouse strains (C57BL/6, FVB/N, and NZB), yet absent from others (AKR, BALB/c, CBA/J, C3H, DBA/1, DBA/2, NOD, SJL, and 129). Putative subsets of NK cells and their expression of NK1.1 antigen are of continuing interest, including NK1.1+/CD117+ (c-Kit) cells reported to be immunosuppressive for CD8+ T cells in a mechanism involving PD-1 and PD-L1. (Ehlers et al. 2012. Endocrinology. 10: 1247.)The PK136 antibody may be used for detection of NK1.1 expression on mouse strains including CE, B6, NZB, C58, Ma/My, ST, SJL, and FVB. The antibody is reported to react with an epitope common to NKR-P1B and NKR-P1C alloantigenic forms of NK1.1 (Carlyle et al. 2006. J. Immunol. 176: 7511-7524).
- Gene ID
- 17059
- UniProt
- P27814
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