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H2AFV antibody (C-Term)

H2AFV Reactivity: Drosophila melanogaster WB, ChIP Host: Mouse Monoclonal 10E9-D1 unconjugated
Catalog No. ABIN6971793
  • Target See all H2AFV Antibodies
    H2AFV (H2A Histone Family, Member V (H2AFV))
    Binding Specificity
    • 7
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    C-Term
    Reactivity
    • 13
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Drosophila melanogaster
    Host
    • 11
    • 4
    Mouse
    Clonality
    • 11
    • 4
    Monoclonal
    Conjugate
    • 11
    • 2
    • 1
    • 1
    This H2AFV antibody is un-conjugated
    Application
    • 8
    • 7
    • 4
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Chromatin Immunoprecipitation (ChIP)
    Characteristics
    The nucleosome is the smallest subunit of chromatin and consists of 147 base pairs of DNA wrapped around an octamer of core histone proteins (two each of Histone H2A, Histone H2B, Histone H3 and Histone H4). Histone H2A.Z (H2AZ, H2AFZ) is a histone H2A variant, a protein similar to canonical H2A but with different molecular identity and unique functions. H2A.Z is highly conserved during evolution. It plays an important role in basic cellular mechanisms such as gene activation, chromosome segregation, heterochromatic silencing and progression through the cell cycle.In Drosophila, the H2A variant corresponding to H2AZ is H2Av. H2Av is an essential protein in Drosophila and has been implicated in both activation and repression of transcription. H2Av is localized to centromeric heterochromatin in Drosophila and flies lacking H2Av have reduced levels of heterochromatin components at the centromeres. However, H2Av nucleosome distribution throughout the rest of the Drosophila genome correlates with genes that have an open and uniform chromatin architecture at promoter regions. Histone H2Av antibody (mAb) (Clone 10E9.D1) was raised in a Mouse host. It has been validated for use in Chromatin Immunoprecipitation and Western blot, it has been shown to react with Drosophila samples.
    Purification
    Protein A Chromatography
    Immunogen
    This antibody was raised against a peptide in the C-terminus of the Drosophila melanogaster Histone variant H2Av.
    Clone
    10E9-D1
    Isotype
    IgG2a
    Top Product
    Discover our top product H2AFV Primary Antibody
  • Application Notes
    Optimal working dilution should be determined by the investigator.
    Restrictions
    For Research Use only
  • Buffer
    Purified IgG in PBS with 30 % glycerol and 0.035 % sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions for storage at -20°C for up to 2 years. Keep all reagents on ice when not in storage.
  • Target
    H2AFV (H2A Histone Family, Member V (H2AFV))
    Alternative Name
    Histone H2Av (H2AFV Products)
    Synonyms
    H2A.Z-2 antibody, H2afv antibody, H2AV antibody, h2av antibody, C530002L11Rik antibody, H2a.z-2 antibody, H2av antibody, H2A.F/Z antibody, h2afv antibody, h2afz antibody, H2A histone family, member V antibody, H2A histone family member V antibody, H2A histone family member V S homeolog antibody, H2A histone family, member Va antibody, H2afv antibody, LOC100226437 antibody, H2AFV antibody, h2afv.S antibody, h2afva antibody
    Molecular Weight
    15 kDa
    NCBI Accession
    NP_524519
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