GRK2 antibody (pSer670) (FITC)

Catalog No. ABIN6986859

The FITC-conjugated Rabbit Polyclonal anti-GRK2 antibody (ABIN6986859) specifically detects GRK2 in IF (p) and IF (cc). The antibody is reactive with Human samples.

Quick Overview for GRK2 antibody (pSer670) (FITC) (ABIN6986859)

Target: GRK2 (ADRBK1) (Adrenergic, Beta, Receptor Kinase 1 (ADRBK1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GRK2 antibody is conjugated to FITC

Application: Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunofluorescence (Cultured Cells) (IF (cc))

Product Details anti-GRK2 Antibody (FITC)

Binding Specificity: pSer670

Purpose: phospho-GRK2 (Ser670) Polyclonal Antibody, FITC Conjugated

Cross-Reactivity: Human, Mouse

Predicted Reactivity: Rat,Dog,Cow,Pig,Horse,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthesised phosphopeptide derived from human GRK2 around the phosphorylation site of Ser670

Isotype: IgG

Application Details

Application Notes: IF(IHC-P)(1:50-200), IF(IHC-F)(1:50-200), IF(ICC)(1:50-200)

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for GRK2

Target: GRK2 (ADRBK1) (Adrenergic, Beta, Receptor Kinase 1 (ADRBK1))

Alternative Name: GRK2

Background:

Synonyms: GRK2 (phospho S670), p-GRK2 (phospho S670), G-protein coupled receptor kinase 2, ADRBK 1, ADRBK1, Adrenergic beta receptor kinase 1, BARK 1, BARK, BARK1, Beta adrenergic receptor kinase 1, Beta ARK 1, Beta ARK1, G Protein Coupled Receptor Kinase 2, G protein dependent receptor kinase 2, FLJ16718, GRK 2, ARBK1_HUMAN.

Background: The product of this gene phosphorylates the beta-2-adrenergic receptor and appears to mediate agonist-specific desensitization observed at high agonist concentrations. This protein is an ubiquitous cytosolic enzyme that specifically phosphorylates the activated form of the beta-adrenergic and related G-protein-coupled receptors. Abnormal coupling of beta-adrenergic receptor to G protein is involved in the pathogenesis of the failing heart. [provided by RefSeq].

Gene ID: 156

UniProt: P25098

Pathways: EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Regulation of G-Protein Coupled Receptor Protein Signaling, CXCR4-mediated Signaling Events, G-protein mediated Events, Interaction of EGFR with phospholipase C-gamma, Thromboxane A2 Receptor Signaling