PDE3B antibody (AA 451-550)

Catalog No. ABIN6989567

The Rabbit Polyclonal anti-PDE3B antibody has been validated for WB, ELISA, IF (cc), IF (p), ICC, IHC (fro) and IHC (p). It is suitable to detect PDE3B in samples from Human.

Quick Overview for PDE3B antibody (AA 451-550) (ABIN6989567)

Target: PDE3B (phosphodiesterase 3B, CGMP-Inhibited (PDE3B))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PDE3B antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunocytochemistry (ICC), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-PDE3B Antibody

Binding Specificity: AA 451-550

Cross-Reactivity: Human

Predicted Reactivity: Mouse,Rat,Dog,Pig,Horse,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human PDE3B

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

Target Details for PDE3B

Target: PDE3B (phosphodiesterase 3B, CGMP-Inhibited (PDE3B))

Alternative Name: PDE3B

Background:

Synonyms: 5''-cyclic phosphodiesterase B, Adipocyte cAMP phosphodiesterase cGMP inhibited, AI847709, cAMP Phosphodiesterase, adipocyte, cGMP-inhibited, CGI-PDE B, CGIP1, CGIPDE B, CGIPDE1, cGMP inhibited 3 5 cyclic phosphodiesterase B, CGMP inhibited cAMP phophodiesterase, cGMP-inhibited 3'', Cyclic GMP inhibited phosphodiesterase B, Cyclic GMP-inhibited phosphodiesterase B, Cyclic nucleotide phosphodiesterase, HcGIP1, HcGIP1, rat, homolog of, Pde3b, PDE3B_HUMAN, Phosphodiesterase 3B cGMP inhibited.

Background: PDE3B is found in lymphocytes. The PDE7A1 (HCP1) isozyme and the PDE7A2 proteins, alternate splice products of PDE7A, are highly expressed in skeletal muscle. PDE7B is most highly expressed in pancreas. The PDE family contains proteins that serve tissue-specific roles in regulation of lipolysis, glycogenolysis, myocardial contractility, and smooth muscle relaxation.

Gene ID: 5140

UniProt: Q13370

Pathways: Negative Regulation of Hormone Secretion, Carbohydrate Homeostasis, cAMP Metabolic Process