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SARS-CoV-2 Spike S2 antibody (AA 900-950)

Reactivity: SARS Coronavirus-2 (SARS-CoV-2) ELISA, WB Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN6990131
  • Target See all SARS-CoV-2 Spike S2 Antibodies
    SARS-CoV-2 Spike S2
    Binding Specificity
    • 2
    • 2
    • 1
    AA 900-950
    Reactivity
    SARS Coronavirus-2 (SARS-CoV-2)
    Host
    • 5
    • 4
    • 2
    Rabbit
    Clonality
    • 6
    • 4
    Polyclonal
    Conjugate
    • 8
    • 2
    This SARS-CoV-2 Spike S2 antibody is un-conjugated
    Application
    • 8
    • 3
    • 1
    • 1
    • 1
    ELISA, Western Blotting (WB)
    Purification
    SARS-CoV-2 (COVID-19) Spike Antibody is affinity chromatography purified via peptide column.
    Immunogen
    Anti-SARS-CoV-2 (COVID-19) Spike antibody was raised against a peptide corresponding to 16 amino acids near the center terminus of SARS-CoV-2 (COVID-19) Spike glycoprotein. The immunogen is located within 900-950 amino acids of SARS-CoV-2 (COVID-19) Spike protein.
    Isotype
    IgG
    Top Product
    Discover our top product SARS-CoV-2 Spike S2 Primary Antibody
  • Application Notes
    WB: 1 μ,g/mL.

    Antibody validated: SARS-CoV-2 (COVID-19) Spike antibody can be used for the detection of SARS-CoV-2 (COVID-19) Spike protein in WB. It will detect 2 ng of free peptide at 1 μ,g/mL. All other applications and species not yet tested.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    SARS-CoV-2 (COVID-19) Spike Antibody is supplied in PBS containing 0.02 % sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C,4 °C
    Storage Comment
    SARS-CoV-2 (COVID-19) Spike antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
  • Target
    SARS-CoV-2 Spike S2
    Abstract
    SARS-CoV-2 Spike S2 Products
    Synonyms
    E2 antibody, Surface Glycoprotein antibody, S antibody
    Target Type
    Viral Protein
    Background
    Coronavirus disease 2019 (COVID-19), formerly known as 2019-nCoV acute respiratory disease, is an infectious disease caused by SARS-CoV-2, a virus closely related to the SARS virus (1). The disease is the cause of the 2019-20 coronavirus outbreak (2). The structure of 2019-nCoV consists of the following: a Spike protein (S), hemagglutinin-esterease dimer (HE), a membrane glycoprotein (M), an envelope protein (E) a nucleoclapid protein (N) and RNA. Coronavirus invades cells through Spike (S) glycoproteins, a class I fusion protein. It is the major viral surface protein that coronavirus uses to bind to the human cell surface receptor. It also mediates the fusion of host and viral cell membrane, allowing the virus to enter human cells and begin infection (3). The spike protein is the major target for neutralizing antibodies and vaccine development (4). The protein modeling suggests that there is strong interaction between Spike protein receptor-binding domain and its host receptor angiotensin-converting enzyme 2 (ACE2), which regulate both the cross-species and human-to-human transmissions of COVID-19 (5). The recent study has shown that the SARS-CoV-2 spike protein binds ACE2 with higher affinity than SARS-CoV spike protein (6).
    Gene ID
    43740568
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