Hemagglutinin antibody (AA 17-338)

Catalog No. ABIN6990181

Product Details anti-Hemagglutinin Antibody

Target: Hemagglutinin (HA)

Binding Specificity: AA 17-338

Reactivity: Influenza A Virus H5N1

Host: Mouse

Clonality: Monoclonal

Conjugate: This Hemagglutinin antibody is un-conjugated

Application: ELISA, Western Blotting (WB)

Purification: Hemagglutinin Monoclonal Antibody is Protein A purified.

Immunogen: Recombinant protein corresponding to amino acids 17 - 338 of H5 HA1.

Clone: 4E10C10

Isotype: IgG1, IgG2b

Application Details

Application Notes: Hemagglutinin antibody can be used for detection of H5 HA1 by Western blot at 2.5µg/mL. Hemagglutinin antibody also specifically recognizes Avian H5N1 influenza virus at 2 µg/mL.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Hemagglutinin Monoclonal Antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Hemagglutinin monoclonal antibody can be stored at -20°C, stable for one year.

Target Details for Hemagglutinin

Target: Hemagglutinin (HA)

Alternative Name: Hemagglutinin (HA Products)

Synonyms: hemagglutinin antibody, Hemagglutinin antibody, HA antibody, HA antibody, ha antibody

Target Type: Influenza Protein

Background: Hemagglutinin Monoclonal Antibody: Influenza A virus is a major public health threat, killing more than 30,000 people per year in the USA. Novel influenza virus strains caused by genetic drift and viral recombination emerge periodically to which humans have little or no immunity, resulting in devastating pandemics. Influenza A can exist in a variety of animals, but it is in birds that all subtypes can be found. These subtypes are classified based on the combination of the virus coat glycoproteins hemagglutinin (HA) and neuraminidase (NA) subtypes. HA interacts with host cell surface proteins containing oligosaccharides with terminal sialyl residues. Its extracellular region has two domains (HA1 and HA2), HA1 is cleaved from the main hemagglutinin protein by the host immune system. During 1997, an H5N1 avian influenza virus was determined to be the cause of death in 6 of 18 infected patients in Hong Kong. This more recent virulent strain of H5N1 is now seen in Africa and Europe, as well as in Southeast Asia. There is some evidence of human to human spread of this virus, but it is thought that the efficiency of this type of transmission is low. Virus isolated from a human infected with the H5N1 strain in 1997 could bind to oligosaccharides from human as well as avian sources, indicating its species-jumping ability.

UniProt: Q692M2