TNFRSF21 antibody (N-Term)

Catalog No. ABIN6990307

Product Details anti-TNFRSF21 Antibody

Target: TNFRSF21 (Tumor Necrosis Factor Receptor Superfamily, Member 21 (TNFRSF21))

Binding Specificity: AA 30-80, N-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TNFRSF21 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Purification: DR6 Antibody is Antibody is DEAE purified.

Immunogen: DR6 antibody was raised against a 15 amino acid peptide near the amino terminus of human DR6. The immunogen is located within amino acids 30 - 80 of DR6.

Isotype: IgG

Application Details

Application Notes: DR6 antibody can be used for detection of DR6 by Western blot at 1:500 dilution. An approximately 68 kDa band can be detected.

Antibody validated: Western Blot in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: DR6 Antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,4 °C

Storage Comment: DR6 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Target Details for TNFRSF21

Target: TNFRSF21 (Tumor Necrosis Factor Receptor Superfamily, Member 21 (TNFRSF21))

Alternative Name: DR6 (TNFRSF21 Products)

Synonyms: TNFRSF21 antibody, tnfrsf21 antibody, MGC146356 antibody, BM-018 antibody, CD358 antibody, DR6 antibody, AA959878 antibody, R74815 antibody, TR7 antibody, dr6 antibody, im:6795346 antibody, wu:fa55e01 antibody, wu:fb02e11 antibody, wu:fc29a09 antibody, wu:fi27h08 antibody, TNF receptor superfamily member 21 antibody, tumor necrosis factor receptor superfamily member 21 antibody, tumor necrosis factor receptor superfamily, member 21 antibody, TNFRSF21 antibody, tnfrsf21 antibody, Tnfrsf21 antibody

Background: DR6 Antibody: Apoptosis is induced by certain cytokines including TNF and Fas ligand of the TNF family through their death domain containing receptors, TNF-R1 and Fas. Several novel death receptors including DR3, DR4, and DR5 were recently identified. A new death domain containing receptor in the TNFR family was cloned recently and termed DR6 for death receptor-6. Like TNF-R1, DR6 interacts with death domain containing adapter molecule TRADD. Overexpression of DR6 induces apoptosis and activates NF-κ,B and JNK. DR6 is widely expressed in human tissues and cell lines. The ligand for DR6 has not been identified.

Molecular Weight: 68 kDa

Gene ID: 27242

UniProt: O75509

Pathways: Regulation of Lipid Metabolism by PPARalpha