NOL3 antibody (C-Term)

Catalog No. ABIN6990320

Product Details anti-NOL3 Antibody

Target: NOL3 (Nucleolar Protein 3 (Apoptosis Repressor with CARD Domain) (NOL3))

Binding Specificity: C-Term

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NOL3 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Purification: Nop30 Antibody is affinity chromatography purified via peptide column.

Immunogen: Nop30 antibody was raised against a 14 amino acid synthetic peptide from near the carboxy terminus of human Nop30. The immunogen is located within the last 50 amino acids of Nop30.

Isotype: IgG

Application Details

Application Notes: Nop30 antibody can be used for detection of Nop30 by Western blot at 0.5 - 2 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 0.5 μ,g/mL.

Antibody validated: Western Blot in mouse samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Nop30 Antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,4 °C

Storage Comment: Nop30 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Target Details for NOL3

Target: NOL3 (Nucleolar Protein 3 (Apoptosis Repressor with CARD Domain) (NOL3))

Alternative Name: Nop30 (NOL3 Products)

Synonyms: ARC antibody, FCM antibody, MYP antibody, NOP antibody, NOP30 antibody, B430311C09Rik antibody, MYC antibody, Nop30 antibody, Arc antibody, nucleolar protein 3 antibody, nucleolar protein 3 (apoptosis repressor with CARD domain) antibody, NOL3 antibody, Nol3 antibody

Background: Nop30 Antibody: Apoptosis, also known as programmed cell death, plays major roles in development and normal tissue turnover in addition to tumor formation. Apoptosis is regulated by death domain (DD) and/or caspase recruitment domain (CARD) containing molecules and the caspase family of proteases. CARD domain containing cell death regulators include RAIDD, Apaf-1, caspase-9, and caspase-2. A novel CARD domain containing protein was recently identified and designated ARC for apoptosis repressor with CARD. An alternate splicing isoform of ARC was identified as Nop30. While ARC interacts with caspase-2 and -8 and suppresses apoptosis induced by cell death adapters FADD and TRADD and by cell death receptors Fas, TNFR-1 and DR3, Nop30 multimerizes and binds to the splicing factor SRp30c and may act to influence alternative splice site selection in vivo. The Nop30 antibody will not detect ARC protein.

Gene ID: 8996

NCBI Accession: NP_001171986

UniProt: O60936