TNFSF13 antibody (Extracellular Domain)

Catalog No. ABIN6990366

Product Details anti-TNFSF13 Antibody

Target: TNFSF13 (Tumor Necrosis Factor (Ligand) Superfamily, Member 13 (TNFSF13))

Binding Specificity: AA 180-230, Extracellular Domain

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TNFSF13 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purification: APRIL Antibody is affinity chromatography purified via peptide column.

Immunogen: APRIL antibody was raised against a synthetic peptide corresponding to amino acids within a extracellular domain of human APRIL. The immunogen is located within amino acids 180 - 230 of APRIL.

Isotype: IgG

Application Details

Application Notes: APRIL antibody can be used for detection of APRIL by Western blot at 1 - 4 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 10 μ,g/mL.

Antibody validated: Western Blot in human samples and Immunohistochemistry in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: APRIL Antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,4 °C

Storage Comment: APRIL antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Target Details for TNFSF13

Target: TNFSF13 (Tumor Necrosis Factor (Ligand) Superfamily, Member 13 (TNFSF13))

Alternative Name: APRIL (TNFSF13 Products)

Synonyms: APRIL antibody, CD256 antibody, TALL-2 antibody, TALL2 antibody, TRDL-1 antibody, ZTNF2 antibody, 2310026N09Rik antibody, April antibody, Tall2 antibody, Trdl1 antibody, SLAN antibody, ANP32B antibody, april antibody, tnf13 antibody, TNLG7B antibody, TNF superfamily member 13 antibody, tumor necrosis factor (ligand) superfamily, member 13 antibody, acidic leucine-rich nuclear phosphoprotein 32 family member B antibody, TNFSF13 antibody, Tnfsf13 antibody, LOC494442 antibody, tnfsf13 antibody

Background: APRIL Antibody: Members in the TNF superfamily regulate immune responses and induce apoptosis. A novel member in the TNF family was recently identified by several groups and designated APRIL (for a proliferation-inducing ligand), TALL-2 (for TNF- and ApoL-related Leukocyte-expressed Ligand 2), and TRDL-1α, (for TNF related death ligand 1α,) in human and mouse. Two receptors for APRIL were recently identified and designated TACI and BCMA. APRIL stimulates B and T cell proliferation, triggers humoral immune responses, activates NF-κ,B, and induces cell death. APRIL and its close relative of BlyS and their receptors BCMA and TACI are involved in diseases of autoimmunity and cancer.

Molecular Weight: Predicted: 27 kDa

Observed: 27 kDa

Gene ID: 8741

NCBI Accession: NP_003799

UniProt: O75888

Pathways: Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response