UBE2V1 antibody (C-Term)

Catalog No. ABIN6990484

Product Details anti-UBE2V1 Antibody

Target: UBE2V1 (Ubiquitin-Conjugating Enzyme E2 Variant 1 (UBE2V1))

Binding Specificity: C-Term

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This UBE2V1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Specificity: Anti-UEV1A may also recognize other isoforms of UEV1A.

Purification: UEV1A Antibody is Ion exchange chromatography purified.

Immunogen: UEV1A antibody was raised against a peptide corresponding to 15 amino acids near the C-terminus of human UEV1A. The immunogen is located within the last 50 amino acids of UEV1A.

Isotype: IgG

Application Details

Application Notes: UEV1A antibody can be used for detection of UEV1A by Western blot at 1 to 4 μ,g/mL.

Antibody validated: Western Blot in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: UEV1A Antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,4 °C

Storage Comment: UEV1A antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Target Details for UBE2V1

Target: UBE2V1 (Ubiquitin-Conjugating Enzyme E2 Variant 1 (UBE2V1))

Alternative Name: UEV1A (UBE2V1 Products)

Synonyms: CIR1 antibody, CROC-1 antibody, CROC1 antibody, UBE2V antibody, UEV-1 antibody, UEV1 antibody, UEV1A antibody, 0610011J09Rik antibody, AI256840 antibody, D7Bwg1382e antibody, CROC-1B antibody, ubiquitin conjugating enzyme E2 V1 antibody, ubiquitin-conjugating enzyme E2 variant 1 antibody, UBE2V1 antibody, ube2v1 antibody, Ube2v1 antibody

Background: UEV1A Antibody: Ubiquitin-conjugating enzyme E2 (UEV1) was initially discovered as a protein similar in sequence and structure to the E2 ubiquitin-conjugating enzymes but lacking their enzymatic activity. There are at least two variants and multiple isoforms of UEV1. In particular, UEV1A (Ubiquitin-conjugating enzyme E2 variant 1 isoform A) has recently been shown to be an important component of the Toll-like receptor and IL-1R signaling pathway. Signals from these pathways are relayed by a number of downstream molecules such as MyD88 and tumor necrosis factor receptor associated factor (TRAF6), ultimately activating various kinases and transcription factors. UEV1A is part of a dimeric ubiquitin-conjugating enzyme complex also containing Ubc13 (ubiquitin-conjugating enzyme 13) that together with TRAF6 activates TAK1, a member of the mitogen-activated protein kinase kinase kinase family. The Ubc13-UEV1A complex also mediates the Lys-63 ubiquitination of TRAF-6, and this ubiquitination is essential for TAK1 activation.

Gene ID: 7335

NCBI Accession: NP_954595

UniProt: Q13404

Pathways: TCR Signaling, Fc-epsilon Receptor Signaling Pathway, Activation of Innate immune Response, Toll-Like Receptors Cascades