IL-31 antibody (AA 60-110)

Catalog No. ABIN6990613

Product Details anti-IL-31 Antibody

Target: IL-31 (IL31) (Interleukin 31 (IL31))

Binding Specificity: AA 60-110

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This IL-31 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF)

Purification: IL-31 Antibody is affinity chromatography purified via peptide column.

Immunogen: IL-31 antibody was raised against a 18 amino acid synthetic peptide from near the center of human IL-31. The immunogen is located within amino acids 60 - 110 of IL-31.

Isotype: IgG

Application Details

Application Notes: IL-31 antibody can be used for the detection of IL-31 by Western blot at 2.5 - 10 μ,g/mL. Despite its predicted size, IL-31 runs at approximately 27 - 30 kDa in SDS-PAGE. For immunofluorescence start at 20 μ,g/mL.

Antibody validated: Western Blot in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: IL-31 Antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,4 °C

Storage Comment: IL-31 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Target Details for IL-31

Target: IL-31 (IL31) (Interleukin 31 (IL31))

Alternative Name: IL-31 (IL31 Products)

Synonyms: IL-31 antibody, 1700013B14Rik antibody, IL31 antibody, interleukin 31 antibody, IL31 antibody, Il31 antibody

Background: IL-31 Antibody: Interleukin-31 (IL-31) is a recently discovered T-cell cytokine closely related to IL-6 type cytokines and is preferentially produced by T helper type 2 cells. IL-31 activity is mediated through the ligand-induced oligomerization of a dimeric receptor complex containing IL-31 receptor A and oncostatin M receptor. In response to IL-31 binding, these proteins activate the JAK/STAT and the AKT signaling pathways. RNA levels of IL-31 receptor A and oncostatin M receptor are induced in activated monocytes but are expressed constitutively in epithelial cells. IL-31, when overexpressed in transgenic mice, results in the development of pruritis, alopecia, and skin lesions and in humans may result in atopic dermatitis, suggesting that IL-31 may represent a novel target for antipruritic drug development.

Gene ID: 386653

UniProt: Q6EBC2