TMED10 antibody (AA 70-120)
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- Target See all TMED10 Antibodies
- TMED10 (Transmembrane Emp24-Like Trafficking Protein 10 (TMED10))
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Binding Specificity
- AA 70-120
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Reactivity
- Human, Mouse, Rat
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This TMED10 antibody is un-conjugated
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Application
- Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
- Purification
- TMP21 Antibody is affinity chromatography purified via peptide column.
- Immunogen
- TMP21 antibody was raised against a 18 amino acid synthetic peptide from near the center of human TMP21. The immunogen is located within amino acids 70 - 120 of TMP21.
- Isotype
- IgG
- Top Product
- Discover our top product TMED10 Primary Antibody
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- Application Notes
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TMP21 antibody can be used for detection of TMP21 by Western blot at 0.5 - 2 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 5 μ,g/mL.
Antibody validated: Western Blot in mouse samples and Immunohistochemistry in human samples. All other applications and species not yet tested. - Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 mg/mL
- Buffer
- TMP21 Antibody is supplied in PBS containing 0.02 % sodium azide.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- -20 °C,4 °C
- Storage Comment
- TMP21 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
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- Target
- TMED10 (Transmembrane Emp24-Like Trafficking Protein 10 (TMED10))
- Alternative Name
- TMP21 (TMED10 Products)
- Synonyms
- tmp21 antibody, P24(DELTA) antibody, S31I125 antibody, S31III125 antibody, TMP21 antibody, Tmp-21-I antibody, p23 antibody, 1110014C03Rik antibody, Tmp21 antibody, p24delta1 antibody, fe06g04 antibody, wu:fb98e10 antibody, wu:fe06g04 antibody, zgc:85681 antibody, transmembrane p24 trafficking protein 10 L homeolog antibody, transmembrane p24 trafficking protein 10 antibody, tmed10.L antibody, TMED10 antibody, Tmed10 antibody, tmed10 antibody
- Background
- TMP21 Antibody: TMP21 is a ubiquitously expressed protein that is involved in vesicular targeting and protein transport. More recent experiments have shown that it is also a component in the presenilin complex and modulates the gamma-secretase but not the epsilon-secretase cleavage activity of the amyloid precursor protein. The presenilin complex is composed of the proteins APH1, nicastrin, and PEN2 in addition to presenilin-1. Together, these proteins cleave the amyloid precursor protein at what is known as the gamma- and epsilon-sites and can lead to the accumulation of the Abeta cleavage product that is associated with Alzheimer's disease. Co-immunoprecipitation experiments using antibodies against these proteins also yielded TMP21 indicating that TMP21 may play a role in the regulation of this complex. Suppression of TMP21 expression by siRNA in transfected cells caused increased gamma-secretase activity but not epsilon-secretase activity, and increased Abeta, production, demonstrating that TMP21 can modulate gamma-secretase activity.
- Gene ID
- 10972
- UniProt
- P49755
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