SAMHD1 antibody (C-Term, pThr592)

Catalog No. ABIN6990713

Product Details anti-SAMHD1 Antibody

Target: SAMHD1 (SAM Domain and HD Domain 1 (SAMHD1))

Binding Specificity: C-Term, pThr592

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SAMHD1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (IHC)

Specificity: Phospho-SAMHD1 antibody will only detect the phosphorylated form of SAMHD1.

Purification: SAMHD1 (phospho Thr592) antibody is affinity chromatography purified via peptide column.

Immunogen: Anti-SAMHD1 (phospho Thr592) antibody was raised against a phosphorylated peptide corresponding to 18 amino acids near the carboxy terminus of human Phospho-SAMHD1 surrounding T592.

Isotype: IgG

Application Details

Application Notes: WB: 0.05-1 μ,g/mL, IHC: 2.5 μ,g/mL, IF: 20 μ,g/mL.

Antibody validated: Western Blot in human and mouse samples, Immunohistochemistry and Immunofluorescence in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: SAMHD1 (phospho Thr592) antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,4 °C

Storage Comment: SAMHD1 (phospho Thr592) antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Target Details for SAMHD1

Target: SAMHD1 (SAM Domain and HD Domain 1 (SAMHD1))

Alternative Name: SAMHD1 (SAMHD1 Products)

Synonyms: CHBL2 antibody, DCIP antibody, HDDC1 antibody, MOP-5 antibody, SBBI88 antibody, si:dkeyp-44b8.8 antibody, E330031J07Rik antibody, Mg11 antibody, SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1 antibody, SAM domain and HD domain 1 antibody, SAM domain and HD domain, 1 antibody, SAMHD1 antibody, samhd1 antibody, Samhd1 antibody

Background: The SAM domain and HD domain 1 (SAMHD1) protein is upregulated in response to viral infection and is thought to play a role in innate immunity (1). SAMHD1 blocks the infection of HIV-1 and SIVdeltaVpx before reverse transcription in macrophages and dendritic cells (2), and this restriction is regulated by phosphorylation of SAMHD1 (3). Mutations in this gene have been associated with Aicardi-Goutieres syndrome (1).

Molecular Weight: Predicted: 72kD

Observed: 72 kD kDa

Gene ID: 25939

NCBI Accession: NP_056289

UniProt: Q9Y3Z3