RASD2 antibody (C-Term)

Catalog No. ABIN6990810

Product Details anti-RASD2 Antibody

Target: RASD2 (RASD Family, Member 2 (RASD2))

Binding Specificity: C-Term

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RASD2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purification: TEM2 Antibody is affinity chromatography purified via peptide column.

Immunogen: TEM2 antibody was raised against a 15 amino acid synthetic peptide near the carboxy terminus of the human TEM2. The immunogen is located within the last 50 amino acids of TEM2.

Isotype: IgG

Application Details

Application Notes: TEM2 antibody can be used for detection of TEM2 by Western blot at 1 - 2 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 2.5 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

Antibody validated: Western Blot in human samples, Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: TEM2 Antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,4 °C

Storage Comment: TEM2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Target Details for RASD2

Target: RASD2 (RASD Family, Member 2 (RASD2))

Alternative Name: TEM2 (RASD2 Products)

Synonyms: RASD2 antibody, MGC:4834 antibody, Rhes antibody, TEM2 antibody, 4930526B11Rik antibody, AU045414 antibody, TEM-2 antibody, RASD family member 2 antibody, RASD family, member 2 antibody, RASD2 antibody, Rasd2 antibody

Background: TEM2 Antibody: Rhes, also known as tumor endothelial marker 2 (TEM2), is a small GTP-binding protein that is predominantly expressed in the striatal region of the brain. This protein belongs to the RASD subfamily of Ras-related GTP-binding protein superfamily and is thought to play a role in the normal development and function of the brain as mice lacking this gene showed increased anxiety levels and motor coordination deficits. Rhes was identified as TEM2 through analysis of genes whose expression was upregulated in tumor endothelium. Tumor endothelial markers are significantly up-regulated during angiogenesis and neoangiogenesis that are crucial for the growth of solid tumors. TEMs localized on the cell surface and conserved across species are of particular interest for future development of anti-angiogenic therapies.

Gene ID: 23551

UniProt: Q96D21