Cathelicidin antibody (AA 50-100)

Catalog No. ABIN6990841

Product Details anti-Cathelicidin Antibody

Target: Cathelicidin (CAMP) (Cathelicidin Antimicrobial Peptide (CAMP))

Binding Specificity: AA 50-100

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Cathelicidin antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF)

Purification: Cathelicidin Antibody is affinity chromatography purified via peptide column.

Immunogen: Cathelicidin antibody was raised against a 17 amino acid synthetic peptide near the center of the human Cathelicidin. The immunogen is located within amino acids 50 - 100 of Cathelicidin.

Isotype: IgG

Application Details

Application Notes: Cathelicidin antibody can be used for detection of Cathelicidin by Western blot at 1 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 5 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

Antibody validated: Western Blot in human samples, Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Cathelicidin Antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,4 °C

Storage Comment: Cathelicidin antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Target Details for Cathelicidin

Target: Cathelicidin (CAMP) (Cathelicidin Antimicrobial Peptide (CAMP))

Alternative Name: Cathelicidin (CAMP Products)

Synonyms: CAP-18 antibody, CAP18 antibody, CRAMP antibody, FALL-39 antibody, FALL39 antibody, LL37 antibody, CATH-2 antibody, Cnlp antibody, Cramp antibody, MCLP antibody, CATH-B1 antibody, CATHB1 antibody, CATHL2 antibody, CATHL7 antibody, CAP11 antibody, cathelicidin antimicrobial peptide antibody, CAMP antibody, LOC100136187 antibody, LOC100136439 antibody, Camp antibody

Background: Cathelicidin Antibody: One component of host defense at mucosal surfaces is epithelial-derived antimicrobial peptides. Cathelicidins are one family of antimicrobial peptides characterized by conserved pro-peptide sequences that have been identified in epithelial tissues and some myeloid cells of humans and animals. LL-37/hCAP-18 is the only Cathelicidin found in humans and is expressed in inflammatory and epithelial cells. The presence of these molecules is essential for defense against invasive bacterial infection in skin. Besides their direct antimicrobial function, Cathelicidins have multiple roles in mediating innate and adaptive immunity, such as endotoxin neutralizing, angiogenesis, wound healing and promoting neutrophil chemotaxis and mast cell recruitment. Finally, Cathelicidin antimicrobial peptides qualify as prototypes of innovative drugs that may be used to treat infection and/or modulate the immune response.

Molecular Weight: Predicted: 19 kDa

Observed: 18 kDa

Gene ID: 820

NCBI Accession: NP_004336

UniProt: P49913

Pathways: Cellular Response to Molecule of Bacterial Origin