Hax1b (N-Term) antibody
Reactivity: Human, Mouse, Rat
ELISA, WB
Host: Rabbit
Polyclonal
unconjugated
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- Target
- Hax1b
- Binding Specificity
- N-Term
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Clonality
- Polyclonal
- Application
- ELISA, Western Blotting (WB)
- Specificity
- At least four isoforms of Hax1 are known to exist. This antibody is predicted to recognize Hax1b.
- Purification
- Hax1b Antibody is affinity chromatography purified via peptide column.
- Immunogen
- Hax1b antibody was raised against a 10 amino acid synthetic peptide near the amino terminus of human Hax1b. The immunogen is located within the first 50 amino acids of Hax1b.
- Isotype
- IgG
-
- Application Notes
-
Hax1b antibody can be used for detection of Hax1b by Western blot at 1 - 2 μ,g/mL.
Antibody validated: Western Blot in mouse samples. All other applications and species not yet tested. - Restrictions
- For Research Use only
-
- Format
- Liquid
- Concentration
- 1 mg/mL
- Buffer
- Hax1b Antibody is supplied in PBS containing 0.02 % sodium azide.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- -20 °C,4 °C
- Storage Comment
- Hax1b antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
-
- Target
- Hax1b
- Background
- Hax1b Antibody: The HS-1 associated protein X-1 (Hax1) was initially identified in a yeast two-hybrid assay on the basis of its ability to bind to the hemapoietic cell-specific protein 1 (HS-1). Hax1 possesses anti-apoptotic activity and is structurally related to Bcl-2 family members, including the presence of BH1- and BH2-like domains. It has recently been shown to interact with HIV viral protein R (Vpr), a protein required for viral pathogenesis of HIV and linked to T-cell apoptosis through activation of caspases 3 and 9. Other studies indicate that Hax1-mediated processing of HtrA2 (also known as Omi) by the mitochondrial protease PARL allows survival of lymphocytes and neurons when cytokines are limiting.
- Gene ID
- 10456
- NCBI Accession
- NP_001018238
- UniProt
- O00165
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