LRFN2 antibody (C-Term)

Catalog No. ABIN6991076

Product Details anti-LRFN2 Antibody

Target: LRFN2 (Leucine Rich Repeat and Fibronectin Type III Domain Containing 2 (LRFN2))

Binding Specificity: AA 700-750, C-Term

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This LRFN2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF)

Specificity: At least two isoforms of LRFN2 are known to exist. This antibody is predicted to not cross-react with other members of the LRFN family.

Purification: LRFN2 Antibody is affinity chromatography purified via peptide column.

Immunogen: LRFN2 antibody was raised against a 14 amino acid synthetic peptide near the carboxy terminus of human LRFN2. The immunogen is located within amino acids 700 - 750 of LRFN2.

Isotype: IgG

Application Details

Application Notes: LRFN2 antibody can be used for detection of LRFN2 by Western blot at 1 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 2.5 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

Antibody validated: Western Blot in mouse and rat samples, Immunohistochemistry in mouse samples and Immunofluorescence in mouse samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: LRFN2 Antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,4 °C

Storage Comment: LRFN2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Target Details for LRFN2

Target: LRFN2 (Leucine Rich Repeat and Fibronectin Type III Domain Containing 2 (LRFN2))

Alternative Name: LRFN2 (LRFN2 Products)

Synonyms: FIGLER2 antibody, KIAA1246 antibody, RP11-535K1.2 antibody, SALM1 antibody, 5730420O05Rik antibody, mKIAA1246 antibody, Salm1 antibody, leucine rich repeat and fibronectin type III domain containing 2 antibody, LRFN2 antibody, Lrfn2 antibody

Background: LRFN2 Antibody: LRFN2 is one of a family of five transmembrane glycoproteins that are highly expressed in neuronal tissues. LRFN proteins share leucine-rich repeat (LRR)-immunoglobulin-like (Ig)-fibronectin type III (Fn)-transmembrane domain structure with other members of the LRR-Ig-Fn protein superfamily such as the Slitrk family of proteins. Expression of LRFN1, -3, and -4 mRNA was detected in embryonic neuronal cells, while Lrfn2 and Lrfn5 expression was primarily restricted to more mature cells. LRFN1, -2, and -4 bound to PDZ domains of postsynaptic PSD95, re-distributing PSD95 to the cell periphery. It has been suggested that the Lrfn proteins play a role in the developing and/or mature vertebrate nervous system.

Molecular Weight: Predicted: 90 kDa

Observed: 100 kDa 

Gene ID: 57497

UniProt: Q9ULH4

Pathways: Synaptic Membrane