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FRMPD1 antibody (C-Term)

FRMPD1 Reactivity: Human WB, ELISA, IF Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN6991211
  • Target See all FRMPD1 Antibodies
    FRMPD1 (FERM and PDZ Domain Containing 1 (FRMPD1))
    Binding Specificity
    • 15
    • 2
    • 1
    • 1
    AA 1330-1380, C-Term
    Reactivity
    Human
    Host
    • 16
    • 2
    • 1
    Rabbit
    Clonality
    • 19
    Polyclonal
    Conjugate
    • 5
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This FRMPD1 antibody is un-conjugated
    Application
    • 18
    • 13
    • 13
    • 4
    • 3
    • 3
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunofluorescence (IF)
    Purification
    FRMPD1 Antibody is affinity chromatography purified via peptide column.
    Immunogen
    FRMPD1 antibody was raised against a 15 amino acid synthetic peptide from near the carboxy terminus of human FRMPD1. The immunogen is located within amino acids 1330 - 1380 of FRMPD1.
    Isotype
    IgG
    Top Product
    Discover our top product FRMPD1 Primary Antibody
  • Application Notes
    FRMPD1 antibody can be used for detection of FRMPD1 by Western blot at 1 - 2 μ,g/mL. Antibody can also be used for immunoflourescence starting at 20 μ,g/mL. For immunofluorescence start at 5 μ,g/mL.

    Antibody validated: Western Blot in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    FRMPD1 Antibody is supplied in PBS containing 0.02 % sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C,4 °C
    Storage Comment
    FRMPD1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
  • Target
    FRMPD1 (FERM and PDZ Domain Containing 1 (FRMPD1))
    Alternative Name
    FRMPD1 (FRMPD1 Products)
    Synonyms
    FRMD2 antibody, BC031840 antibody, mKIAA0967 antibody, FERM and PDZ domain containing 1 antibody, FRMPD1 antibody, Frmpd1 antibody
    Background
    FRMPD1 Antibody: The FERM and PDZ domain containing (FRMPD) protein family consists of four proteins that contain a FERM (Four-point-one, erzin, radixin, moesin) domain and at least one PDZ (PSD-95/Discs large/Zonula-occuldens-1) domain. FRMPD1 was initially identified through a yeast two-hybrid screening with Activator of G-protein signaling 3 (AGS3), a protein that acts to stabilize the GDP-bound conformation of Gai, as the bait. FRMPD1 binds to the tetratricopeptide repeat of AGS3 and stabilizes AGS3 in a membrane environment. Suppression of FRMPD1 in Cath.a-differentiated neuronal cells decreased the level of endogenous AGS3 in membrane fractions by ~50 % and enhanced the inhibition of forskolin-induced increases in cAMP. Co-immunoprecipitation studies indicate that the interaction of AGS3 with FRMPD1 is mutually exclusive with the interaction of AGS3 with Gai3, suggesting that FRMPD1 may position AGS3 in the membrane where it can then interact with Galphai.
    Gene ID
    22844
    NCBI Accession
    NP_055722
    UniProt
    Q5SYB0
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