NLRP4 antibody (AA 330-380)

Catalog No. ABIN6991401

Product Details anti-NLRP4 Antibody

Target: NLRP4 (NLR Family, Pyrin Domain Containing 4 (NLRP4))

Binding Specificity: AA 330-380

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NLRP4 antibody is un-conjugated

Application: ELISA, Western Blotting (WB)

Purification: NALP4 Antibody is affinity chromatography purified via peptide column.

Immunogen: NALP4 antibody was raised against a 13 amino acid synthetic peptide near the center of human NALP4. The immunogen is located within amino acids 330 - 380 of NALP4.

Isotype: IgG

Application Details

Application Notes: NALP4 antibody can be used for detection of NALP4 by Western blot at 1 μ,g/mL.

Antibody validated: Western Blot in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: NALP4 Antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,4 °C

Storage Comment: NALP4 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Target Details for NLRP4

Target: NLRP4 (NLR Family, Pyrin Domain Containing 4 (NLRP4))

Alternative Name: NALP4 (NLRP4 Products)

Synonyms: CLR19.5 antibody, CT58 antibody, NALP4 antibody, PAN2 antibody, PYPAF4 antibody, RNH2 antibody, Nalp4 antibody, Nlrp4e antibody, RGD1563529 antibody, NLR family pyrin domain containing 4 antibody, NLR family, pyrin domain containing 4 antibody, NLRP4 antibody, Nlrp4 antibody

Background: NALP4 Antibody: NALP proteins include the apoptosis regulator APAF1 (apoptotic protease activating factor 1) and mammalian NOD-LRR proteins and are thought to be involved in inflammation and reproduction. NALP4, also known as PYRIN-containing APAF1-like protein 4, has a C-terminal leucine-rich repeat (LRR) region, an N-terminal Pyrin domain (PYD) followed by a NACHT domain, and a NACHT-associated domain. In transfected 293 cells, NALP4 suppressed NF-κ,B induction by TNF-α, and IL-1β, suggesting NALP4 operates at a point of convergence in these two signaling pathways. NALP4 also suppressed NF-κ,B induction resulting from overexpression of several adapter proteins and protein kinases involved in these pathways, including TRAF2, TRAF6, RIP, and IRAK2, as well as the IKK-alpha and IKK-beta, suggesting that NALP4 is critical in modulating NF-κ,B activity.

Gene ID: 147945

UniProt: Q96MN2

Pathways: Inflammasome