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CXXC4 antibody (N-Term)

CXXC4 Reactivity: Human, Mouse, Rat WB, ELISA, IHC (p), IF Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN6991438
  • Target See all CXXC4 Antibodies
    CXXC4 (CXXC Finger Protein 4 (CXXC4))
    Binding Specificity
    • 10
    • 8
    • 7
    • 2
    • 2
    • 1
    AA 50-100, N-Term
    Reactivity
    • 22
    • 13
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    Human, Mouse, Rat
    Host
    • 21
    • 1
    Rabbit
    Clonality
    • 22
    Polyclonal
    Conjugate
    • 12
    • 2
    • 2
    • 2
    • 2
    • 2
    This CXXC4 antibody is un-conjugated
    Application
    • 21
    • 16
    • 15
    • 14
    • 3
    • 2
    Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF)
    Purification
    CXXC4 Antibody is affinity chromatography purified via peptide column.
    Immunogen
    CXXC4 antibody was raised against an 18 amino acid synthetic peptide near the amino terminus of human CXXC4. The immunogen is located within amino acids 50 - 100 of CXXC4.
    Isotype
    IgG
    Top Product
    Discover our top product CXXC4 Primary Antibody
  • Application Notes
    CXXC4 antibody can be used for detection of CXXC4 by Western blot at 1 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 10 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

    Antibody validated: Western Blot in human samples, Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    CXXC4 Antibody is supplied in PBS containing 0.02 % sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C,4 °C
    Storage Comment
    CXXC4 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
  • Target
    CXXC4 (CXXC Finger Protein 4 (CXXC4))
    Alternative Name
    CXXC4 (CXXC4 Products)
    Synonyms
    9330210J02Rik antibody, C030003J12Rik antibody, Idax antibody, IDAX antibody, Xldax antibody, xIdax antibody, CXXC finger 4 antibody, CXXC finger protein 4 antibody, CXXC finger protein 4 S homeolog antibody, Cxxc4 antibody, CXXC4 antibody, cxxc4.S antibody
    Background
    CXXC4 Antibody: CXXC4 is zinc finger protein that binds directly to the PDZ domain of DVL1, a protein involved in the Wnt signaling pathway, through its C-terminal region. CXXC4's interaction with DVL1 competes with DVL1-AXIN binding, although the affinity of DVL1 for CXXC4 is lower than that for AXIN. In mouse fibroblasts, CXXC4 suppressed Wnt3a induction of beta-catenin and inhibited Wnt3a-dependent TCF4 activation, suggesting that CXXC4 acts as a negative regulator of the Wnt signaling pathway and functions between DVL and beta-catenin. Recent reports suggest that decreased CXXC4 expression is associated with kidney cancer metastasis, cell proliferation, reduced apoptosis in response to cancer drugs, and upregulation of genes involved with proliferation, invasion and cell survival, suggesting that CXXC4 plays a critical role in tumor progression in kidney cancer.
    Gene ID
    80319
    NCBI Accession
    NP_079488
    UniProt
    Q9H2H0
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