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TRMT12 antibody (N-Term)

TRMT12 Reactivity: Human, Mouse ELISA, WB, ICC Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN6991541
  • Target See all TRMT12 Antibodies
    TRMT12 (tRNA Methyltransferase 12 Homolog (TRMT12))
    Binding Specificity
    • 2
    • 1
    N-Term
    Reactivity
    • 11
    • 8
    • 1
    Human, Mouse
    Host
    • 10
    • 1
    Rabbit
    Clonality
    • 11
    Polyclonal
    Conjugate
    • 4
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This TRMT12 antibody is un-conjugated
    Application
    • 3
    • 2
    • 1
    • 1
    • 1
    ELISA, Western Blotting (WB), Immunocytochemistry (ICC)
    Specificity
    TYW2 antibody is predicted to not cross-react with other TYW protein family members. At least two isoforms of TYW2 are known to exist, this antibody will detect both isoforms
    Purification
    TYW2 Antibody is affinity chromatography purified via peptide column.
    Immunogen
    TYW2 antibody was raised against a 19 amino acid synthetic peptide near the amino terminus of human TYW2. The immunogen is located within the first 50 amino acids of TYW2.
    Isotype
    IgG
    Top Product
    Discover our top product TRMT12 Primary Antibody
  • Application Notes
    TYW2 antibody can be used for detection of TYW2 by Western blot at 0.5 μ,g/mL. Antibody can also be used for immunocytochemistry starting at 10 μ,g/mL.

    Antibody validated: Western Blot in human samples and Immunocytochemistry in human samples. All other applications and species not yet tested.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    TYW2 Antibody is supplied in PBS containing 0.02 % sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C
    Storage Comment
    TYW2 antibody can be stored at 4 °C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
  • Target
    TRMT12 (tRNA Methyltransferase 12 Homolog (TRMT12))
    Alternative Name
    TYW2 (TRMT12 Products)
    Synonyms
    4632406N01Rik antibody, AI449275 antibody, Tyw2 antibody, TRM12 antibody, TYW2 antibody, RGD1307127 antibody, trmt12 antibody, tRNA methyltranferase 12 antibody, tRNA methyltransferase 12 homolog antibody, tRNA methyltransferase 12 antibody, tRNA methyltransferase 12 homolog (S. cerevisiae) antibody, Trmt12 antibody, TRMT12 antibody, trmt12 antibody
    Background
    TYW2 Antibody: TYW2, also known as TRM12, is an enzyme that participates in the wybutosine-tRNA (Phe) biosynthesis pathway. Wybutosine (yW) is a hypermodified guanosine at the 3-prime position adjacent to the anticodon of phenylalanine tRNA that stabilizes codon-anticodon interactions during decoding on the ribosome. TYW2 is involved in a multistep enzymatic reaction that stabilizes codon-anticodon base-pairing during the ribosomal decoding process, thereby ensuring correct translation. TYW2 was found to be amplified in 7 of 8 breast cancers cell lines analyzed, and qPCR analysis of 30 breast tumors showed overexpression of TYW2 mRNA of over 2-fold in 26, suggesting that TYW2 may play a role in breast cancer.
    Gene ID
    55039
    UniProt
    Q53H54
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