TMEM59L antibody (C-Term)

Catalog No. ABIN6991563

Product Details anti-TMEM59L Antibody

Target: TMEM59L (Transmembrane Protein 59-Like (TMEM59L))

Binding Specificity: AA 220-270, C-Term

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TMEM59L antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF)

Specificity: Multiple isoforms of TMEM59L are known to exist. TMEM59L antibody is predicted to not cross-react TMEM59.

Purification: TMEM59L Antibody is affinity chromatography purified via peptide column.

Immunogen: TMEM59L antibody was raised against a 19 amino acid synthetic peptide near carboxy terminus of human TMEM59L. The immunogen is located within amino acids 220 - 270 of TMEM59L.

Isotype: IgG

Application Details

Application Notes: TMEM59L antibody can be used for detection of TMEM59L by Western blot at 1 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 2.5 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

Antibody validated: Western Blot in rat samples, Immunohistochemistry in mouse samples and Immunofluorescence in mouse samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: TMEM59L Antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,4 °C

Storage Comment: TMEM59L antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Target Details for TMEM59L

Target: TMEM59L (Transmembrane Protein 59-Like (TMEM59L))

Alternative Name: TMEM59L (TMEM59L Products)

Synonyms: LOC719572 antibody, BSMAP antibody, C19orf4 antibody, 5330410G16Rik antibody, RGD1305557 antibody, transmembrane protein 59 like antibody, transmembrane protein 59-like antibody, TMEM59L antibody, Tmem59l antibody

Background: TMEM59L Antibody: Processing of the amyloid precursor protein (APP) by two different proteases, called alpha- and beta-secretase, is a central regulatory event in the generation of the amyloid beta peptide (Abeta), which has a key role in Alzheimer disease (AD) pathogenesis. TMEM59L is a type I membrane glycoprotein that is expressed in the brain. A related protein, TMEM59, is a Golgi-localized protein that modulates the O-glycosylation and complex N-glycosylation steps occurring during the Golgi maturation of several proteins such as APP, BACE1, SEAP or PRNP and inhibits APP transport and shedding.

Gene ID: 25789

NCBI Accession: NP_036241

UniProt: Q9UK28