ZGPAT antibody (C-Term)

Catalog No. ABIN6991617

Product Details anti-ZGPAT Antibody

Target: ZGPAT (Zinc Finger, CCCH-Type with G Patch Domain (ZGPAT))

Binding Specificity: C-Term

Reactivity: Human

Host: Chicken

Clonality: Polyclonal

Conjugate: This ZGPAT antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF)

Specificity: Multiple isoforms of ZGPAT are known to exist.

Purification: ZGPAT Antibody is affinity chromatography purified via peptide column.

Immunogen: ZGPAT antibody was raised against a 15 amino acid synthetic peptide near the carboxy terminus of human ZGPAT. The immunogen is located within the last 50 amino acids of ZGPAT.

Isotype: IgY

Application Details

Application Notes: ZGPAT antibody can be used for detection of ZGPAT by Western blot at 1 μ,g/mL. Antibody can also be used for immunofluorescence starting at 20 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

Antibody validated: Western Blot in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: ZGPAT Antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,4 °C

Storage Comment: ZGPAT antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Target Details for ZGPAT

Target: ZGPAT (Zinc Finger, CCCH-Type with G Patch Domain (ZGPAT))

Alternative Name: ZGPAT (ZGPAT Products)

Synonyms: zc3h9 antibody, gpatc6 antibody, gpatch6 antibody, zc3hdc9 antibody, GPATC6 antibody, GPATCH6 antibody, KIAA1847 antibody, ZC3H9 antibody, ZC3HDC9 antibody, ZIP antibody, 1500006I01Rik antibody, BC021513 antibody, RGD1310801 antibody, zgc:63730 antibody, zinc finger CCCH-type and G-patch domain containing antibody, zinc finger, CCCH-type with G-patch domain L homeolog antibody, zinc finger, CCCH-type with G-patch domain antibody, zinc finger, CCCH-type with G patch domain antibody, ZGPAT antibody, zgpat.L antibody, zgpat antibody, Zgpat antibody

Background: ZGPAT Antibody: The Zinc finger CCCH-type with G patch domain-containing protein (ZGPAT), is a transcriptional repressor that regulates several cellular pathways including EGFR pathways that are involved in cell proliferation, migration and survival. ZGPAT recruits the Mi-2/NuRD complex and represses the expression of EGFR. ZGPAT is down-regulated in breast carcinomas and its expression is negatively correlated with that of EGFR, suggesting that it may be a potential target for breast cancer therapy. Multiple isoforms of ZGPAT are known to exist, including sZIP, which binds to the Mi-2/NuRD complex but lacks the DNA binding component of full-length ZGPAT, thereby antagonizing transcription repression and growth inhibition by ZGPAT.

Gene ID: 84619

NCBI Accession: NP_115916

UniProt: Q8N5A5

Pathways: EGFR Signaling Pathway