RAPGEF4 antibody (N-Term)

Catalog No. ABIN6991626

Product Details anti-RAPGEF4 Antibody

Target: RAPGEF4 (Rap Guanine Nucleotide Exchange Factor (GEF) 4 (RAPGEF4))

Binding Specificity: N-Term

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RAPGEF4 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Specificity: At least two isoforms of EPAC2 are known to exist, this antibody will detect only the larger isoform. EPAC2 antibody is predicted to not cross-react with EPAC2

Purification: EPAC2 Antibody is affinity chromatography purified via peptide column.

Immunogen: EPAC2 antibody was raised against a 15 amino acid synthetic peptide near the amino terminus of human EPAC2. The immunogen is located within the first 50 amino acids of EPAC2.

Isotype: IgG

Application Details

Application Notes: EPAC2 antibody can be used for detection of EPAC1 by Western blot at 1 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 2.5 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

Antibody validated: Western Blot in rat samples, Immunohistochemistry in mouse samples and Immunofluorescence in mouse samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: EPAC2 Antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,4 °C

Storage Comment: EPAC2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Target Details for RAPGEF4

Target: RAPGEF4 (Rap Guanine Nucleotide Exchange Factor (GEF) 4 (RAPGEF4))

Alternative Name: EPAC2 (RAPGEF4 Products)

Synonyms: RAPGEF4 antibody, CAMP-GEFII antibody, CGEF2 antibody, EPAC2 antibody, Nbla00496 antibody, 1300003D15Rik antibody, 5730402K07Rik antibody, 6330581N18Rik antibody, EPAC 2 antibody, Epac-2 antibody, Epac2 antibody, mKIAA4040 antibody, CAMPS antibody, Cgef2 antibody, Rap guanine nucleotide exchange factor 4 antibody, rap guanine nucleotide exchange factor 4 antibody, Rap guanine nucleotide exchange factor (GEF) 4 antibody, RAPGEF4 antibody, LOC579050 antibody, LOC100551109 antibody, PTRG_05798 antibody, Rapgef4 antibody

Background: EPAC2 Antibody: EPAC2, also known as Rap guanine nuclear exchange factor 4 and cAMPGEF-II, is belongs to a family of cyclic adenosine monophosphate (cAMP) binding proteins with guanine nucleotide exchange factor. Like the related protein EPAC1, EPAC2 signaling plays a role in numerous cellular processes such as integrin-mediated cell adhesion, muscle contraction, learning and memory, cell proliferation, and inflammation. Recent evidence suggests that EPAC2 induces synapse remodeling and depression, with mutations in its gene being found in patients with autism.

Gene ID: 11069

NCBI Accession: NP_008954

UniProt: Q8WZA2

Pathways: Hormone Transport, Smooth Muscle Cell Migration