GRB10 antibody (C-Term)

Catalog No. ABIN6991650

Product Details anti-GRB10 Antibody

Target: GRB10 (Growth Factor Receptor-Bound Protein 10 (GRB10))

Binding Specificity: AA 440-490, C-Term

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GRB10 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF)

Specificity: At least three isoforms of GRB10 are known to exist, this antibody will detect all three isoforms.

Purification: GRB10 Antibody is affinity chromatography purified via peptide column.

Immunogen: GRB10 antibody was raised against a 17 amino acid synthetic peptide near the carboxy terminus of human GRB10. The immunogen is located within amino acids 440 - 490 of GRB10.

Isotype: IgG

Application Details

Application Notes: GRB10 antibody can be used for detection of GRB10 by Western blot at 1 - 2 μ,g/mL. Antibody can also be used for immunofluorescence starting at 20 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

Antibody validated: Western Blot in human samples and Immunofluorescence in rat samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: GRB10 Antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,4 °C

Storage Comment: GRB10 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Target Details for GRB10

Target: GRB10 (Growth Factor Receptor-Bound Protein 10 (GRB10))

Alternative Name: GRB10 (GRB10 Products)

Synonyms: grb10 antibody, zgc:91987 antibody, GRB10 antibody, grb-10 antibody, grb-ir antibody, irbp antibody, meg1 antibody, rss antibody, LOC100224775 antibody, 5730571D09Rik antibody, AI325020 antibody, Meg1 antibody, mKIAA0207 antibody, RGD1566234 antibody, GRB-IR antibody, Grb-10 antibody, IRBP antibody, MEG1 antibody, RSS antibody, growth factor receptor bound protein 10 antibody, growth factor receptor-bound protein 10a antibody, growth factor receptor bound protein 10 L homeolog antibody, growth factor receptor-bound protein 10 antibody, GRB10 antibody, grb10a antibody, grb10 antibody, grb10.L antibody, LOC100434903 antibody, Grb10 antibody

Background: GRB10 Antibody: GRB10 belongs to a small family of adapter proteins that are known to interact with a number of receptor tyrosine kinases and signaling molecules and function in diverse cellular processes. GRB10 is a growth factor receptor-binding protein that interacts with insulin receptors and insulin-like growth-factor receptors. Overexpression of some isoforms of GRB10 inhibits tyrosine kinase activity and results in growth suppression. GRB10 can also interact with the L isoform of the proapoptotic protein Bim. This gene is imprinted in a highly isoform- and tissue-specific manner, with expression observed from the paternal allele in the brain, and from the maternal allele in the placental trophoblasts.

Gene ID: 2887

NCBI Accession: NP_005302

UniProt: Q13322

Pathways: Regulation of Carbohydrate Metabolic Process, Signaling Events mediated by VEGFR1 and VEGFR2