CASK antibody (N-Term)

Catalog No. ABIN6991711

Product Details anti-CASK Antibody

Target: CASK (Calcium/calmodulin-Dependent serine Protein Kinase (MAGUK Family) (CASK))

Binding Specificity: AA 760-810, N-Term

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CASK antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF)

Specificity: At least six alternatively spliced transcript variants have been observed.

Purification: CASK Antibody is affinity chromatography purified via peptide column.

Immunogen: CASK antibody was raised against a 16 amino acid synthetic peptide near the amino terminus of human CASK. The immunogen is located within amino acids 760 - 810 of CASK.

Isotype: IgG

Application Details

Application Notes: CASK antibody can be used for detection of CASK by Western blot at 1 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

Antibody validated: Western Blot in mouse samples and Immunofluorescence in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: CASK Antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,4 °C

Storage Comment: CASK antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Target Details for CASK

Target: CASK (Calcium/calmodulin-Dependent serine Protein Kinase (MAGUK Family) (CASK))

Alternative Name: CASK (CASK Products)

Synonyms: CAKI antibody, CAMGUK antibody, CG13412 antibody, CG13413 antibody, CG6703 antibody, CMG antibody, CMG/CASK antibody, Caki antibody, CamGUK antibody, CamguK antibody, Camguk antibody, Cask antibody, Cmg antibody, DLin-2 antibody, Dmel\\CG6703 antibody, RE09582p antibody, caki antibody, camguk antibody, cmg antibody, dCASK antibody, wu:fb70g06 antibody, CAGH39 antibody, FGS4 antibody, LIN2 antibody, MICPCH antibody, MRXSNA antibody, TNRC8 antibody, DXPri1 antibody, DXRib1 antibody, LIN-2 antibody, Pals3 antibody, mLin-2 antibody, CG6703 gene product from transcript CG6703-RF antibody, Peripheral plasma membrane protein CASK antibody, CAMK/CASK protein kinase antibody, peripheral plasma membrane protein CASK antibody, calcium/calmodulin-dependent serine protein kinase b antibody, calcium/calmodulin-dependent serine protein kinase a antibody, calcium/calmodulin dependent serine protein kinase antibody, calcium/calmodulin-dependent serine protein kinase (MAGUK family) antibody, calcium/calmodulin-dependent serine protein kinase (MAGUK family) S homeolog antibody, CASK antibody, Bm1_33725 antibody, LOAG_17286 antibody, Tsp_03763 antibody, caskb antibody, caska antibody, Cask antibody, cask.S antibody

Background: CASK Antibody: CASK (Calcium/calmodulin-dependent serine protein kinase), a conserved multi-domain scaffolding protein, belongs to a MAGUK (membrane-associated guanylate kinase homologs) subfamily and is involved in cell junction organization, tumor suppression and signaling. It is characterized by a novel domain structure that consists of a calcium/calmodulin-dependent protein kinase domain followed by PDZ, SH3 and guanylate kinase-like (GUK) domains. CASK is ubiquitously expressed and significantly greater in brain where it is thought to be involved in signaling at neuronal synapses. CASK interacts with CASKINs and defects in CASK are the cause of mental retardation X-linked CASK-related.

Gene ID: 8573

NCBI Accession: NP_003679

UniProt: O14936

Pathways: Synaptic Vesicle Exocytosis