RAB21 antibody (C-Term)

Catalog No. ABIN6991713

Product Details anti-RAB21 Antibody

Target: RAB21 (RAB21, Member RAS Oncogene Family (RAB21))

Binding Specificity: C-Term

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RAB21 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF)

Specificity: This antibody is predicted to not cross-react with other Ras-related proteins

Purification: RAB21 Antibody is affinity chromatography purified via peptide column.

Immunogen: RAB21 antibody was raised against a 19 amino acid synthetic peptide near the carboxy terminus of human RAB21. The immunogen is located within the last 50 amino acids of RAB21.

Isotype: IgG

Application Details

Application Notes: RAB21 antibody can be used for detection of RAB21 by Western blot at 1 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

Antibody validated: Western Blot in mouse samples and Immunofluorescence in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: RAB21 Antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,4 °C

Storage Comment: RAB21 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Target Details for RAB21

Target: RAB21 (RAB21, Member RAS Oncogene Family (RAB21))

Alternative Name: RAB21 (RAB21 Products)

Synonyms: MGC68816 antibody, RAB21 antibody, 9630024B22 antibody, RAB21, member RAS oncogene family antibody, RAB21, member RAS oncogene family L homeolog antibody, RAB21 antibody, rab21.L antibody, rab21 antibody, Rab21 antibody

Background: RAB21 Antibody: RAB21 is a member of a subfamily of small GTP-binding protein genes of the Ras superfamily that plays an important role in intracellular vesicular targeting. In non-polarized Caco-2 cells, RAB21 showed a general endoplasmic reticulum (ER)-like localization, while in polarized cells, RAB21 localized to apical vesicles. RAB21 has been shown to associate with integrin subunits and to be important for receptor entry into cells via RAB5/RAB21 endosomes. The GTPase-activating protein p120RasGAP regulates cell motility by controlling the return of the endocytosed integrins to the plasma membrane by competing with RAB21 for binding to overlapping sites on the α,-tail of endocytosed integrin.

Gene ID: 23011

NCBI Accession: NP_055814

UniProt: Q9UL25