TCIRG1 antibody (N-Term)

Catalog No. ABIN6991729

This Rabbit Polyclonal antibody specifically detects TCIRG1 in WB and ELISA. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for TCIRG1 antibody (N-Term) (ABIN6991729)

Target: TCIRG1 (T-Cell, Immune Regulator 1, ATPase, H+ Transporting, Lysosomal V0 Subunit A3 (TCIRG1))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TCIRG1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-TCIRG1 Antibody

Binding Specificity: AA 70-120, N-Term

Specificity: At least two alternatively spliced isoforms are known to exist, this antibody will only detect the larger isoform.

Purification: TCIRG1 Antibody is affinity chromatography purified via peptide column.

Immunogen: TCIRG1 antibody was raised against a 19 amino acid synthetic peptide near the amino terminus of human TCIRG1. The immunogen is located within amino acids 70 - 120 of TCIRG1.

Isotype: IgG

Application Details

Application Notes: TCIRG1 antibody can be used for detection of TCIRG1 by Western blot at 0.5 μ,g/mL.

Antibody validated: Western Blot in mouse samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: TCIRG1 Antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,4 °C

Storage Comment: TCIRG1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Target Details for TCIRG1

Target: TCIRG1 (T-Cell, Immune Regulator 1, ATPase, H+ Transporting, Lysosomal V0 Subunit A3 (TCIRG1))

Alternative Name: TCIRG1

Background: TCIRG1 Antibody: The T-cell immune regulator 1 (TCIRG1) is the a3 subunit of the vacuolar-type proton transporting ATPase (V-ATPase), a proton pump in late endosomes and lysosomes that functions in the luminal acidification of these organelles. Genetic defects in the gene encoding this protein a responsible for a severe form of autosomal recessive osteopetrosis, a condition that leads to increased bone density, decreased bone strength, and inflammation in bone tissues. TCIRG1 is also required for the normal secretion of insulin and the bacteria-killing function of macrophages.

Molecular Weight: 91 kDa

Gene ID: 10312

NCBI Accession: NP_006010

UniProt: Q13488

Pathways: Transition Metal Ion Homeostasis, Proton Transport